Hemostasis vs. epidural fibrosis?: A comparative study on an experimental rat model of laminectomy

Basit Öğe Kaydı
dc.authorid0000-0002-8313-4092en_US
dc.authorid0000-0002-5300-4449en_US
dc.authorid0000-0002-1347-8498en_US
dc.contributor.authorErdogan, Hakan
dc.contributor.authorKelten, Bilal
dc.contributor.authorTuncdemir, Matem
dc.contributor.authorErturkuner, Salime Pelin
dc.contributor.authorUzun, Hafize
dc.contributor.authorKaraoglan, Alper
dc.date.accessioned2024-07-12T21:52:27Z
dc.date.available2024-07-12T21:52:27Z
dc.date.issued2016en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAim: The aim of this study was to evaluate the histopathological and biochemical impact and effectiveness of two hemostatic agents, Ankaferd blood stopper (ABS) and Microporous Polysaccharide Hemospheres (MPH), on epidural fibrosis in an experimental rat laminectomy model. Material and methods: Twenty adult Wistar albino rats were divided into MPH-treated (n = 6), ABS-treated (n = 6) and control (n = 8) groups. Laminectomy of the lumbar spine was performed in all animals and treatment groups were exposed to MPH and ABS while closure was applied in control group as per usual. Epidural fibrosis was evaluated in all groups macroscopically, histopathologically, biochemically and with electron microscopy four weeks later. Results: Statistically, it was found that MPH-treated group had significantly less epidural fibrosis compared to ABS-treated and control groups. Conclusion: We compared two hemostatic agents for their propensity to cause adhesions in the present study. Our results show that MPH significantly reduces epidural scar formation and dural adhesion in a rat model of laminectomy while ABS increases postoperative fibrosis. (C) 2016 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.en_US
dc.identifier.doi10.1016/j.pjnns.2016.05.002
dc.identifier.endpage330en_US
dc.identifier.issn0028-3843
dc.identifier.issue5en_US
dc.identifier.pmid27591056en_US
dc.identifier.scopus2-s2.0-84973570806en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.pjnns.2016.05.002
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8371
dc.identifier.volume50en_US
dc.identifier.wosWOS:000384518000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTERMEDIA PUBLISHING HOUSE LTDen_US
dc.relation.ispartofNEUROLOGIA I NEUROCHIRURGIA POLSKAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03094
dc.subjectEpidural fibrosisen_US
dc.subjectHemostasisen_US
dc.subjectLaminectomyen_US
dc.subjectRatsen_US
dc.titleHemostasis vs. epidural fibrosis?: A comparative study on an experimental rat model of laminectomyen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu