Reduction of cisplatin ototoxicity in rats by oral administration of pomegranate extract

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dc.authorid0000-0002-6197-7654en_US
dc.contributor.authorYazici, Zahide Mine
dc.contributor.authorMeric, Aysenur
dc.contributor.authorMidi, Ahmet
dc.contributor.authorAranc, Yasar Volkan
dc.contributor.authorKahya, Volkan
dc.contributor.authorHafaz, Gunter
dc.date.accessioned2024-07-12T21:46:26Z
dc.date.available2024-07-12T21:46:26Z
dc.date.issued2012en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effectiveness of the oral administration of pomegranate extract (PE) as a protective agent against cisplatin-induced ototoxicity. The study included a prospective, controlled animal study Group 1 (n = 6), received no cisplatin or PE, and group 2 (n = 6) received cisplatin at 8 mg/kg/day for 3 consecutive days. Group 3 (n = 6) received not only cisplatin at 8 mg/kg/day for 3 consecutive days, but also received PE (100 mu L/day) via gavage for 5 days prior to the cisplatin injection and for 3 days concomitantly with the cisplatin injections. To measure cisplatin ototoxic effects, "distortion product otoacoustic emissions" (DPOAE) were analyzed 3 days before and after the cisplatin injections. Histological changes in the cochleas were observed by light microscopy. Compared with group 3, the DPOAE amplitudes of group 2 decreased significantly. Among the groups, there was a statistically significant difference in basal and mid turn external ciliated cells (ECC) number, but there was no statistically significant difference in apical turn. Differences in stria vascularis (SV) changes were statistically significant between the groups, and the median score for SV injury was significantly greater in group 2 than in group 3. Differences in the median scores for SGC changes being significantly greater in group 2 than in group 3. In conclusion, these results indicated that oral administration of PE afforded statistically significant protection to the cochlea in rats from cisplatin toxicity, and thus, oral experimental dose of PE administration may have a protective effect against cisplatin ototoxicity in rats.en_US
dc.identifier.doi10.1007/s00405-011-1582-2
dc.identifier.endpage52en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue1en_US
dc.identifier.pmid21442422en_US
dc.identifier.scopus2-s2.0-84857061670en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-011-1582-2
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7934
dc.identifier.volume269en_US
dc.identifier.wosWOS:000298655300008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00833
dc.subjectCisplatinen_US
dc.subjectOtotoxicityen_US
dc.subjectPomegranateen_US
dc.subjectHistopathologyen_US
dc.titleReduction of cisplatin ototoxicity in rats by oral administration of pomegranate extracten_US
dc.typeArticle
dspace.entity.typePublication

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