Comparison of the acute alterations in serum bone turnover markers and bone mineral density among women with surgical menopause

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dc.contributor.authorBahar, Sengul
dc.contributor.authorAbali, Remzi
dc.contributor.authorGuzel, Savas
dc.contributor.authorBozkurt, Serpil
dc.contributor.authorGuzel, Eda Celik
dc.contributor.authorAral, Hale
dc.contributor.authorBoran, Ahmet Birtan
dc.date.accessioned2024-07-12T21:46:37Z
dc.date.available2024-07-12T21:46:37Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy on serum turnover markers and to examine their correlation with bone mineral density (BMD). Study design: This study included 51 women who had regular menses preoperatively and underwent bilateral oophorectomy for benign reasons. These women did not have any systemic disease or drug use that would influence bone metabolism. For each woman, spine and femur BMD were measured preoperatively and sixth months after surgery. Serum C-terminal telopeptide (CTX) and bone alkaline phosphatase (BAP) were measured preoperatively and at the first and sixth months after surgery. Correlations between bone turnover markers and BMD were pre- and post-operatively analyzed. Results: The mean serum CTX and BAP concentrations at the first and sixth postoperative months were significantly higher compared to the preoperative measurements (p = 0.001). Spine BMD values at the sixth postoperative month was significantly lower compared to preoperative period (p = 0.0001). There was a significant negative correlation between spine BMD values and BAP levels both in the preoperative period and at the sixth postoperative month (r = -0.407, p = 0.001), whereas a significant positive correlation between serum CTX and BAP was noted at this time periods (r = 0.615, p < 0.001). Conclusions: The results of this study showed that serum BAP and CTX levels rapidly increase in women after bilateral oophorectomy. Therefore, these markers (especially BAP) could be useful in the evaluation of osteoporosis risk in the early period of surgical menopause. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2011.06.033
dc.identifier.endpage197en_US
dc.identifier.issn0301-2115
dc.identifier.issue1en_US
dc.identifier.pmid21764505en_US
dc.identifier.scopus2-s2.0-81855221947en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage194en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejogrb.2011.06.033
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7950
dc.identifier.volume159en_US
dc.identifier.wosWOS:000298202800039en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00861
dc.subjectSurgical menopauseen_US
dc.subjectBone turnoveren_US
dc.subjectSerum C-terminal telopeptideen_US
dc.subjectBone mineral densityen_US
dc.subjectBone specific alkaline phosphataseen_US
dc.titleComparison of the acute alterations in serum bone turnover markers and bone mineral density among women with surgical menopauseen_US
dc.typeArticle
dspace.entity.typePublication

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