The expression of CD44, CD90 and CD133 in response to cisplatin in hepatocellular cancer cells

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dc.authorid0000-0002-4605-1167en_US
dc.authorid0000-0002-3060-1507en_US
dc.authorid0000-0003-0674-090Xen_US
dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorDönmez Çakıl, Yaprak
dc.contributor.authorÖzünal, Zeynep Güneş
dc.contributor.authorGökçeoğlu Kayalı, Damla
dc.contributor.authorAktaş, Ranan Gülhan
dc.date.accessioned2024-07-12T21:03:36Z
dc.date.available2024-07-12T21:03:36Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIntroduction. Cancer is a leading cause of mortality. Hepatocellular cancer is one of the malignancies associated with poor outcome and resistance to pharmacotherapy. Cancer stem cells (CSCs) contribute to resistance to therapy and hence lead to the treatment failure of tumors. Aim. This study aims to explore the expression of CSCs in response to cisplatin treatment in HepG2 hepatocellular cancer cell line. Material and methods. Cell proliferation test, CCK-8, was used to evaluate the cell proliferation following cisplatin treatment for 72 hours. The expressions of CSC markers CD44, CD90, and CD133 were assessed by flow cytometric analysis. Results. The results showed a dose-dependent decrease in cell proliferation and increased expression of CSC markers CD44 and CD90 in response to cisplatin. Conclusion. Understanding the roles of CSC markers may point to new targets and therapeutic strategies to predict and overcome cisplatin resistance.en_US
dc.identifier.citationDönmez Çakıl, Y., Özünal, Z.G., Gökçeoğlu Kayalı, D. ve Aktaş, R.G. (2021). The expression of CD44, CD90 and CD133 in response to cisplatin in hepatocellular cancer cells. 19(1), s. 18-22.en_US
dc.identifier.endpage22en_US
dc.identifier.issn2544-1361
dc.identifier.issue1en_US
dc.identifier.startpage18en_US
dc.identifier.urihttps://bibliotekanauki.pl/articles/2040155
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3683
dc.identifier.volume19en_US
dc.institutionauthorDönmez Çakıl, Yaprak
dc.institutionauthorÖzünal, Zeynep Güneş
dc.institutionauthorGökçeoğlu Kayalı, Damla
dc.institutionauthorAktaş, Ranan Gülhan
dc.language.isoenen_US
dc.publisherUniwersytet Rzeszowskien_US
dc.relation.ispartofEuropean Journal of Clinical and Experimental Medicineen_US
dc.relation.isversionof10.15584/ejcem.2021.1.3en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00844
dc.subjectcanceren_US
dc.subjectcisplatinen_US
dc.subjecthepatocellularen_US
dc.subjectstem cellsen_US
dc.titleThe expression of CD44, CD90 and CD133 in response to cisplatin in hepatocellular cancer cellsen_US
dc.typeArticle
dspace.entity.typePublication

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