A grubu beta-hemolitik streptokokların antibiyotik duyarlılıkları
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Antibiyotik ve Kemoterapi Derneği
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A grubu beta-hemolitik streptokoklar (Streptococcus pyogenes) bakteriyel farenjitlerin en sık saptanan etkenidir. Penisilin ve diğer beta-laktam antibiyotiklere henüz direnç bildirilmemiştir. Ancak, penisilin allerjisi olan veya tolerans varlığında hastaların tedavisinde alternatif olan makrolidlere karşı giderek artan oranlarda direnç bildirilmiştir. Bu çalışmada, Ocak 2006-Haziran 2006 tarihlerinde boğaz kültürlerinden izole edilen, 100 S.pyogenes suşunun ampisilin, seftriakson, azitromisin, tetrasiklin, kloramfenikol ve siprofloksasine duyarlılıkları araştırılmıştır. Suşların tümü ampisilin, seftriakson ve azitromisine duyarlı bulunmuştur. En yüksek direnç oranı kloramfenikol için saptanırken (% 19), bunu sırasıyla tetrasiklin (% 14) ve siprofloksasin (% 12) dirençleri izlemiştir. Test ettiğimiz makrolid grubu antibiyotik olan azitromisine karşı direnç olmaması, penisilin allerjisi ya da tolerans varlığında, bu gruptaki antibiyotiklerin üst solunum yolu infeksiyonlarının tedavisinde alternatif olabileceğini düşündürmektedir.
Group A beta-haemolytic streptococci (GABHS) or Streptococcus pyogenes, is the most common cause of acute bacterial pharyngitis. GABHS are still susceptible to penicillin and other beta-lactam antibiotics. Resistance to macrolides, advocated for group A streptococcal infections primarily in cases of beta-lactam allergy or intolerance, has been reported from an increasing number of countries in recent years. In this study, susceptibility to antibiotics of 100 GABHS strains isolated from throat cultures between January-June 2006 was determined by the Clinical Laboratory Standards Institute broth microdilution method. All of strains were susceptible to ampicillin, seftriaxone and azithromycin. Resistance to chloramphenicol was 19 %, to tetracycline was 14 %, to ciprofloxacin was 12 %. According to these results, macrolide antibiotics may be used as alternative treatment agents in patients with penicillin allergy or bacterial tolerance.
Group A beta-haemolytic streptococci (GABHS) or Streptococcus pyogenes, is the most common cause of acute bacterial pharyngitis. GABHS are still susceptible to penicillin and other beta-lactam antibiotics. Resistance to macrolides, advocated for group A streptococcal infections primarily in cases of beta-lactam allergy or intolerance, has been reported from an increasing number of countries in recent years. In this study, susceptibility to antibiotics of 100 GABHS strains isolated from throat cultures between January-June 2006 was determined by the Clinical Laboratory Standards Institute broth microdilution method. All of strains were susceptible to ampicillin, seftriaxone and azithromycin. Resistance to chloramphenicol was 19 %, to tetracycline was 14 %, to ciprofloxacin was 12 %. According to these results, macrolide antibiotics may be used as alternative treatment agents in patients with penicillin allergy or bacterial tolerance.
Açıklama
Anahtar Kelimeler
antibiyotik duyarlılığı, Streptococcus pyogenes, antibiotic susceptibility, Streptococcus pyogenes
Kaynak
ANKEM Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
21
Sayı
1
Künye
Özakkaş, F., Aksungar, F.B. ve Eren Topkaya, A. (2006). A grubu beta-hemolitik streptokokların antibiyotik duyarlılıkları. ANKEM Dergisi, Antibiyotik ve Kemoterapi Derneği. 21(1), s. 10-13.
