Effects of Lower Extremity Revascularization on the Endothelial Functions Measured With Noninvasive Brachial Artery Flow-Mediated Dilatation

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dc.authorid0000-0002-9116-3985en_US
dc.authorid0000-0001-5427-550Xen_US
dc.contributor.authorUnal, Orcun
dc.contributor.authorKaratepe, Oguzhan
dc.contributor.authorUgurlucan, Murat
dc.contributor.authorKoc, Bora
dc.contributor.authorFilizcan, Ugur
dc.contributor.authorAksoy, Murat
dc.date.accessioned2024-07-12T21:45:02Z
dc.date.available2024-07-12T21:45:02Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Endothelial function is best measured with the noninvasive brachial artery flow-mediated dilatation (FMD) method. Peripheral arterial diseases and systemic cardiovascular diseases have FMD-lowering effect. The effects of lower extremity ischemia are associated with muscle inflammation and claudication, which may further lead to arterial stress. Our aim in this study was to investigate the effects of peripheral arterial revascularization on the endothelial functions through noninvasive brachial artery FMD. Methods: Between January 2007 and February 2008, 54 patients diagnosed with lower extremity arterial disease undergoing revascularization were included in the study. Endothelial function is measured preoperatively and at the fourth week postoperatively using the brachial artery FMD method. Blood samples were collected at the same intervals for the measurement of interleukin-6, leukocyte count, tumor necrosis factor-alpha, and nitric oxide values. Results: Femoropopliteal bypass grafting was performed in all patients with a synthetic graft. The mean ankle-brachial index in the preoperative period was 0.29 +/- 0.083, and after the operation, dorsalis pedis and/or posterior tibial artery became palpable in all patients. The nitric oxide, interleukin-6, high-sensitivity C-reactive protein, and tumor necrosis factor-alpha levels decreased significantly after 4 weeks postoperatively as compared with the preoperative levels (p < 0.05). Postoperative Doppler ultrasonography FMD of brachial artery increased from preoperative value of 9.2 +/- 2.1 to 16.2 +/- 4.5 (p < 0.01) at postoperative week 4. Conclusions: Systemic inflammation and muscle ischemia lead to reduced endothelial functions. After successful lower extremity revascularization, endothelial functions improve dramatically, which may be easily detected with the noninvasive brachial artery FMD method.en_US
dc.identifier.doi10.1016/j.avsg.2011.02.013
dc.identifier.endpage974en_US
dc.identifier.issn0890-5096
dc.identifier.issue7en_US
dc.identifier.pmid21530156en_US
dc.identifier.scopus2-s2.0-80052761306en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage969en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.avsg.2011.02.013
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7780
dc.identifier.volume25en_US
dc.identifier.wosWOS:000295305100015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofANNALS OF VASCULAR SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00295
dc.titleEffects of Lower Extremity Revascularization on the Endothelial Functions Measured With Noninvasive Brachial Artery Flow-Mediated Dilatationen_US
dc.typeArticle
dspace.entity.typePublication

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