Do Staphylococcus aureus superantigens play a role in the pathogenesis of otitis media with effusion in children?

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dc.authorid0000-0001-7914-2201en_US
dc.contributor.authorDemir, Deniz
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorGüven, Mehmet
dc.contributor.authorKayabaşoğlu, Gürkan
dc.contributor.authorYılmaz, Mahmut Sinan
dc.contributor.authorDemir, Deniz
dc.date.accessioned2024-07-12T21:00:36Z
dc.date.available2024-07-12T21:00:36Z
dc.date.issued2016en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjectives Staphylococcal enterotoxins (SEs), acting as superantigens, have been reported to be involved in the pathogenesis of chronic inflammatory diseases of the upper and lower airway. There has been no previous study investigating the role of SEs in otitis media with effusion (OME). Therefore, this study was designed to analyze middle ear aspirates from children with and without OME for the presence of SEs. Methods Middle ear aspirates were obtained from 24 patients and 24 controls. All samples were processed for bacterial culture and detection of five staphylococcal SEs (SEA, SEB, SEC and SED) and toxic shock syndrome toxin-1 using the Rapid Latex Agglutination Test. Results In bacterial culture assays, six samples (25%) of the study group and five samples (20.8%) of the control group showed bacterial growth. At least one SE was demonstrated in 6 of 24 patients and in 3 of 24 controls. There was no statistically significant difference between the two groups with respect to the presence of SEs. Conclusion Although there is evidence that SEs have a potential role in the pathogenesis of chronic inflammatory diseases, there is no evidence that the inflammation process is initiated by SEs in patients with OME.en_US
dc.identifier.citationDemir, D., Karabay, O., Güven, M., Kayabaşoğlu, G. ve Yılmaz, M.S. (2016). Do Staphylococcus aureus superantigens play a role in the pathogenesis of otitis media with effusion in children?. International Journal of Pediatric Otorhinolaryngology, Elsevier. 84, s. 71-74.en_US
dc.identifier.endpage74en_US
dc.identifier.issn1872-8464
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165587616000872
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3402
dc.identifier.volume84en_US
dc.institutionauthorDemir, Deniz
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.isversionof10.1016/j.ijporl.2016.02.028en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01675
dc.subjectBacteriaen_US
dc.subjectBiofilmen_US
dc.subjectOtitis media with effusionen_US
dc.subjectMyringotomyen_US
dc.subjectEnterotoxinen_US
dc.titleDo Staphylococcus aureus superantigens play a role in the pathogenesis of otitis media with effusion in children?en_US
dc.typeArticle
dspace.entity.typePublication

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