A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats

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dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorCebe, Tamer
dc.contributor.authorYanar, Karolin
dc.contributor.authorAtukeren, Pınar
dc.contributor.authorOzan, Tuna
dc.contributor.authorKuruç, Aylin Irmak
dc.contributor.authorKunbaz, Ahmad
dc.contributor.authorSitar, Mustafa Erinç
dc.contributor.authorMengi, Murat
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorAydın, Şeval
dc.contributor.authorÇakatay, Ufuk
dc.date.accessioned2024-07-12T21:01:23Z
dc.date.available2024-07-12T21:01:23Z
dc.date.issued2014en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractAge-related myocardial dysfunction has important implications with impaired redox homeostasis. Current study focused on investigation of redox homeostasis and histopathological changes in the myocardium of mimetically (MA), naturally aged (NA), and young control (YC) rats. Chronic d-galactose administration to young male Wistar rats (5 months old) was used to set up experimental aging models. We investigated 16 different oxidative damage biomarkers which have evaluated redox homeostasis of cellular macromolecules such as protein, lipid, and DNA. As a protein oxidation biomarker, advanced oxidation end products, protein carbonyl groups, protein-bound advanced glycation end products, dityrosine, kynurenine, and N-formylkynurenine concentrations in MA and NA rats were found to be significantly higher compared to those in YC rats. On the other hand, the levels of protein thiol groups were not significantly different between groups, whereas lipid peroxidation biomarkers such as conjugated diens, lipid hydroperoxides, and malondialdehyde in MA and NA rats were found to be significantly higher in comparison to those in YCs. For the assessment of oxidative DNA damage, we analyzed eight hydroxy-5?-deoxyguanosine concentrations of MA and NA groups which were higher than YCs. As an antioxidant status in the MA and NA groups, Cu–Zn superoxide dismutase, ferric reducing antioxidant power, and total thiol levels were lower than those in the YCs. Only nonprotein thiol levels were not significantly different. We also observed similar histopathological changes in MA and NA rats. We concluded that the mimetic aging model could be considered as a reliable experimental model for myocardial senescence.en_US
dc.identifier.citationCebe, T., Yanar, K., Atukeren, P. vd. (2014). A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats. Age (Dordr), National Library of Medicine. 36(6), s. 1-14.en_US
dc.identifier.endpage14en_US
dc.identifier.issn1574-4647
dc.identifier.issue6en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226800/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3497
dc.identifier.volume36en_US
dc.institutionauthorSitar, Mustafa Erinç
dc.language.isoenen_US
dc.publisherNational Library of Medicineen_US
dc.relation.ispartofAge (Dordr)en_US
dc.relation.isversionof10.1007/s11357-014-9728-yen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00126
dc.subjectMyocardial agingen_US
dc.subjectd-Galactoseen_US
dc.subjectProtein oxidationen_US
dc.subjectLipid peroxidationen_US
dc.subjectAntioxidant capacityen_US
dc.subjectDNA oxidationen_US
dc.titleA comprehensive study of myocardial redox homeostasis in naturally and mimetically aged ratsen_US
dc.typeArticle
dspace.entity.typePublication

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