Escitalopram increases cortical nitric oxide synthase (NOS) in rat brain during ethanol withdrawal

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dc.authorid0000-0002-6423-4207en_US
dc.authorid0000-0003-4601-7871en_US
dc.authorid0000-0002-0021-8400en_US
dc.contributor.authorSaglam, Esra
dc.contributor.authorAtes, Lora Esberk
dc.contributor.authorKayir, Hakan
dc.contributor.authorCelik, Turgay
dc.contributor.authorTerzioglu, Berna
dc.contributor.authorUzbay, Tayfun
dc.date.accessioned2024-07-12T21:52:29Z
dc.date.available2024-07-12T21:52:29Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe effect of escitalopram on ethanol withdrawal syndrome (EWS) and involvement of nitric oxide system in rats was investigated. Male Wistar rats divided into five experimental groups of eight animals each: (a) control group; (b) EWS (saline) group; (c) escitalopram 2.5 mg group; (d) escitalopram 5 mg group and (e) escitalopram 10 mg group. Ethanol dependence was induced in rats by ethanol-containing liquid diet and ethanol withdrawal was precipitated by replacing ethanol free diet. Ethanol receiving rats in individual groups were decapitated on 21st day of ethanol ingestion and at sixth hour of ethanol withdrawal. Brains were removed and dissected. Five regions of the brain were dissected: the frontal cortex, cerebellum, striatum, hippocampus and hypothalamus. Immunohistochemical NOS staining was performed. The NOS staining intensity in cortex and hypothalamus regions were significantly lower in EWS group than control group. During EWS period, in rats given 2.5 and 10 mg/kg escitalopram, the staining intensity in cortex, striatum and hippocampus were found to be 11.492, 8.519 and 11.234, respectively, and was statistically different than the control group. The hippocampal NOS staining intensity was found to be significantly decreased with 2.5 mg/kg escitalopram, whereas the cortex, striatum and hippocampal staining intensity were increased significantly with 5 mg/kg. In 10 mg/kg escitalopram group, staining properties were not different than those of the control group. Our results suggest that NOS decreases during ethanol withdrawal in cortex and hypothalamus of rat brain and treatment with escitalopram reverses the enzyme density in cortex but not hypothalamus. (c) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.niox.2008.06.222
dc.identifier.endpage288en_US
dc.identifier.issn1089-8603
dc.identifier.issue3en_US
dc.identifier.pmid18640281en_US
dc.identifier.scopus2-s2.0-52149120536en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage284en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.niox.2008.06.222
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8384
dc.identifier.volume19en_US
dc.identifier.wosWOS:000260020600007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofNITRIC OXIDE-BIOLOGY AND CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03116
dc.subjectEscitalopramen_US
dc.subjectNitric oxide synthaseen_US
dc.subjectEthanol withdrawalen_US
dc.subjectRat(s)en_US
dc.titleEscitalopram increases cortical nitric oxide synthase (NOS) in rat brain during ethanol withdrawalen_US
dc.typeArticle
dspace.entity.typePublication

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