Effect of the pneumococcal conjugate vaccine on pneumococcal carriage in Turkish children

Basit Öğe Kaydı
dc.contributor.authorErcan, Tugba E.
dc.contributor.authorSeverge, Burcu
dc.contributor.authorTopkaya, Aynur
dc.contributor.authorErcan, R. Goekmen
dc.contributor.authorAltinkaya, Nuevit
dc.date.accessioned2024-07-12T21:52:44Z
dc.date.available2024-07-12T21:52:44Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: The aim of our study was to evaluate the effect of the seven-valent pneumococcal conjugate vaccine which has recently been included in the national immunization schedule on the nasopharyngeal carriage of Streptococcus pneumoniae in a group of healthy Turkish children. This is the first study determining the efficacy of this vaccine in Turkey. Methods: One hundred and thirty-eight children who had completed their pneumococcal vaccination series and 109 unvaccinated control subjects aged 12-59 months were included in the study between October 2007 and April 2008. A single nasopharyngeal swab sample was obtained from each subject. Results: S. pneumoniae was isolated in 32 (12.9%) of 247 subjects. No significant differences were detected in pneumococcal carriage rate between the vaccinees and controls (10.1% vs 16.5%). Prevalence of vaccine type (VT) carriage was statistically lower in the vaccinated group than the controls while non-vaccine type carriage (NVT) was similar. Most frequently isolated vaccine serotype was 23F in the vaccinated group and 19F in the non-vaccinated group. Of the isolated S. pneumoniae, 13.3% were penicillin susceptible and 86.7% were non-susceptible. Vaccinees and controls did not differ statistically with respect to carriage rate of penicillin-resistant S. pneumoniae. All the pneumococcal isolates were susceptible to ceftriaxone, vancomycin, rifampicin and quinolones. Conclusion: Seven-valent conjugate vaccine induces long-term protection against carriage of VT S. pneumoniae in Turkish children. The ability of the conjugate vaccine to reduce transmission of antibiotic resistant S. pneumoniae may be possible if its introduction is coupled with a reduction in inappropriate use of antibiotics.en_US
dc.identifier.doi10.1111/j.1442-200X.2010.03212.x
dc.identifier.endpage230en_US
dc.identifier.issn1328-8067
dc.identifier.issue2en_US
dc.identifier.pmid21501306en_US
dc.identifier.scopus2-s2.0-79955072733en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage224en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1442-200X.2010.03212.x
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8425
dc.identifier.volume53en_US
dc.identifier.wosWOS:000289683100017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofPEDIATRICS INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03214
dc.subjectnasopharyngeal carriageen_US
dc.subjectseven-valent pneumococcal conjugate vaccineen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.subjectvaccine serotypesen_US
dc.titleEffect of the pneumococcal conjugate vaccine on pneumococcal carriage in Turkish childrenen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu