Huge prosthetic mitral valve thrombosis in a pregnant woman

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dc.contributor.authorÖzkan, Mehmet
dc.contributor.authorBiteker, Murat
dc.contributor.authorEkşi Duran, Nilüfer
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned2024-07-12T21:02:59Z
dc.date.available2024-07-12T21:02:59Z
dc.date.issued2009en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractA 42-year-old woman in her 30th week of pregnancy who had undergone a mitral valve replacement with a 29-mm St. Jude Medical mechanical prosthetic valve (St. Jude Medical, St. Paul, Minn) 2 years earlier was referred to our hospital with severe dyspnea. She had a history of irregular and subtherapeutic use of enoxaparin 6000 IU/d until admission. Transthoracic echocardiography revealed a mean diastolic mitral transvalvular gradient of 29 mm Hg, mitral valve area of 0.6 cm2, and a giant thrombus with mobile components on the prosthetic valve (Figure 1; online-only Data Supplement Movie I). In spite of the large prosthetic mitral valve thrombosis, she had no history of thromboembolism. Two-dimensional transesophageal echocardiography revealed an unprecedentedly large thrombus (6 cm2 in area) appended to the mitral valve that was restricting the movement of 1 of the leaflets (Figure 2; online-only Data Supplement Movie II). Real-time 3-dimensional transesophageal echocardiography demonstrated restriction of 1 of the leaflets with a thrombus located on the left atrial side of the mitral valve (Figure 3; online-only Data Supplement Movie III). After the patient was given a low-dose (25 mg), slow-infusion (6 hours) tissue plasminogen activator without bolus administration 3 times (for a total of 75 mg), 3-dimensional transesophageal echocardiography showed complete thrombolysis (Figure 4; online-only Data Supplement Movie IV). The mean transprosthetic mitral valve gradient decreased to 4 mm Hg, and mitral valve area increased to 2.7 cm2.en_US
dc.identifier.citationÖzkan, M., Biteker, M., Ekşi Duran, N. ve Yıldız, M. (2009). Huge prosthetic mitral valve thrombosis in a pregnant woman. Circulation. 120(18), s. 151-152.en_US
dc.identifier.endpage152en_US
dc.identifier.issue18en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.873786
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3608
dc.identifier.volume120en_US
dc.institutionauthorEkşi Duran, Nilüfer
dc.language.isoenen_US
dc.publisherThe American Heart Associationen_US
dc.relation.ispartofCirculationen_US
dc.relation.isversionof10.1161/CIRCULATIONAHA.109.873786en_US
dc.relation.publicationcategoryUlusal Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00508
dc.titleHuge prosthetic mitral valve thrombosis in a pregnant womanen_US
dc.typeArticle
dspace.entity.typePublication

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