Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting

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dc.contributor.authorAksungar, Fehime B.
dc.contributor.authorTopkaya, Aynur E.
dc.contributor.authorAkyildiz, Mahmut
dc.date.accessioned2024-07-12T21:45:00Z
dc.date.available2024-07-12T21:45:00Z
dc.date.issued2007en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: It is well known that nutritional habits, sleeping patterns and meal frequency have profound effects on maintaining human health. Ramadan is a religious month for Islam, during which Muslims do not eat and drink during the daylight hours. The duration of restricted food and beverage intake is approximately 12 h/day for 1 month, which makes Ramadan a model of prolonged intermittent fasting. Methods: In order to evaluate the effects of long- lasting modifications of food intake on inflammatory markers and biochemical parameters 40 healthy volunteers of normal weight [ 20 females aged between 20 and 38 years, 20 males aged between 23 and 39 years, body mass index (BMI) < 25 kg/m(2)] who fasted during Ramadan and another 28 healthy age and BMI-matched volunteers (14 males, 14 females) who did not fast participated in the study. Venous blood samples were taken 1 week before Ramadan, during the last week of Ramadan and 3 weeks after Ramadan. Serum interleukin-6 (IL-6), C-reactive protein (CRP), homocysteine, vitamin B-12, folate, total cholesterol (TC), triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Results: No significant changes were observed in serum total cholesterol, triglycerides and LDL levels. TC/HDL ratio (HDL risk factor) was decreased during and after Ramadan in both genders in the fasting group while there were no changes in the nonfasting group. IL-6 (p < 0.001), CRP (p < 0.001) and homocysteine (p < 0.01) levels were significantly low during Ramadan in the fasting subjects of both genders when compared to basal values (1 week before Ramadan). Conclusion: Our results demonstrate that prolonged intermittent fasting in a model like Ramadan has some positive effects on the inflammatory status of the body and on the risk factors for cardiovascular diseases such as homocysteine, CRP and TC/HDL ratio. Copyright (c) 2007 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000100954
dc.identifier.endpage95en_US
dc.identifier.issn0250-6807
dc.identifier.issn1421-9697
dc.identifier.issue1en_US
dc.identifier.pmid17374948en_US
dc.identifier.scopus2-s2.0-34247483580en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000100954
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7770
dc.identifier.volume51en_US
dc.identifier.wosWOS:000246173700013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofANNALS OF NUTRITION AND METABOLISMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00264
dc.subjectramadanen_US
dc.subjectfastingen_US
dc.subjectinterleukin-6en_US
dc.subjectC-reactive proteinen_US
dc.subjecthomocysteineen_US
dc.subjecthigh-density lipoproteinen_US
dc.subjectvitamin B-12en_US
dc.subjectfolateen_US
dc.titleInterleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fastingen_US
dc.typeArticle
dspace.entity.typePublication

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