The impact of oocyte denudation without a pre-incubation on intracytoplasmic sperm injection outcomes

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dc.authorid0000-0001-5641-3785en_US
dc.authorid0000-0002-0717-1756en_US
dc.authorid0000-0002-4605-1167en_US
dc.authorid0000-0002-1029-7691en_US
dc.authorid0000-0003-4478-7514en_US
dc.contributor.authorKanaat, Şenay
dc.contributor.authorSelam, Belgin
dc.contributor.authorDüzgün, Zehra Beyza
dc.contributor.authorCincik, Mehmet
dc.contributor.authorDönmez Çakıl, Yaprak
dc.date.accessioned2024-07-12T21:03:55Z
dc.date.available2024-07-12T21:03:55Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractAims: Debate over the optimal timing of oocyte denudation following oocyte retrieval continues. Multinucleation has been associated with lower embryo quality and implantation rate. Defining oocyte characteristics might increase the chances of better embryo selection. This study aimed to investigate the laboratory and clinical outcomes of intracytoplasmic sperm injection when the oocytes were denuded immediately after oocyte retrieval. Methods: A prospective randomized sibling-oocyte study was performed. The participants were under 40 years of age with more than 5 oocytes. Patients with male factors were excluded. The study and control groups were formed by simple randomization. The study group underwent oocyte denudation immediately. In the control group, oocytes were routinely incubated in an equilibration solution for 2 h until the removal of the cumulus cells. Outcome measures were normal fertilization (two pronuclei, 2PN), multinucleation rate, the proportion of good quality embryos, blastocyst formation, and pregnancy rate. Results: A total of 792 oocytes were collected from 54 participants (mean age: 30.6±3.7 years). The fertilization rate was higher in the study group (n=209 in 376) compared with the controls (n=201 in 416) (55.6% vs. 48.3%, p=0.041). The multinucleation rate (6.6% vs. 4.3%, p=0.150), proportion of grade 1 embryos on day 3 (48.7% vs. 43%, p=0.112) and day 5 (27.7% vs. 23.8%, p=0.214), the proportion of embryos reaching blastocyst stage (34.0% vs. 28.1%, p=0.072), and the pregnancy rates (78.6% vs. 71.4%, p=1.000) were similar. Conclusions: Our results demonstrated that immediate removal of cumulus cells does not have any negative impact on intracytoplasmic sperm injection outcomes.en_US
dc.identifier.citationDüzgün, Z.B., Cıncık, M., Dönmez Çakıl, Y., Kanaat, Ş. ve Selam, B. (2022). The impact of oocyte denudation without a pre-incubation on intracytoplasmic sperm injection outcomes. Gülhane Medical Journal, Gülhane Faculty of Medicine.64(3): s. 235-239.en_US
dc.identifier.doi10.4274/gulhane.galenos.2022.59454
dc.identifier.endpage239en_US
dc.identifier.issn2146-8052
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85138067825en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage235en_US
dc.identifier.trdizinid1124087en_US
dc.identifier.urihttps://gulhanemedj.org/archives/archive-detail/article-preview/the-impact-of-oocyte-denudation-without-a-pre-incu/52870
dc.identifier.urihttps://doi.prg/10.4274/gulhane.galenos.2022.59454
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3729
dc.identifier.volume64en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorDüzgün, Zehra Beyza
dc.institutionauthorCincik, Mehmet
dc.institutionauthorDönmez Çakıl, Yaprak
dc.language.isoenen_US
dc.publisherGülhane Faculty of Medicineen_US
dc.relation.ispartofGülhane Medical Journalen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01101
dc.subjectICSIen_US
dc.subjectmultinucleationen_US
dc.subjectdenudationen_US
dc.subjectembryo qualityen_US
dc.subjectfertilizationen_US
dc.subjectpregnancyen_US
dc.titleThe impact of oocyte denudation without a pre-incubation on intracytoplasmic sperm injection outcomesen_US
dc.typeArticle
dspace.entity.typePublication

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