Blood oxidative stres biomarkers in patients with Familial Mediterranean Fever (FMF)

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dc.authorid0000-0002-0752-4515en_US
dc.authorid0000-0003-2045-1709en_US
dc.contributor.authorÇelik, Serkan
dc.contributor.authorÖktenli, Çağatay
dc.contributor.authorTerekeci, Murat Hakan
dc.contributor.authorİpçioğlu, Osman
dc.contributor.authorSanisoğlu, Yavuz S.
dc.contributor.authorSayan, Özkan
dc.contributor.authorYeşilova, Zeki
dc.contributor.authorYıldız, Oğuzhan
dc.contributor.authorTunca, Yusuf
dc.contributor.authorNalbant, Selim
dc.date.accessioned2024-07-12T21:01:24Z
dc.date.available2024-07-12T21:01:24Z
dc.date.issued2010en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractInterest in the relationship between oxidative stress and inflammation has increased in recent years. Familial Mediterranean fever (FMF) represents a suitable autoinflammatory disease model for investigation of this relationship. We aimed to determine blood oxidative stress biomarkers in patients with FMF in both acute attacks and in attack-free periods, and to evaluate its associations with pyrine mutations and C-reactive protein (CRP) levels. The mean levels of CRP and serum lipid hydroperoxide were higher and serum superoxide dismutase and catalase activities were lower in patients with FMF than in healthy volunteers. Serum lipid hydroperoxide levels were higher and antioxidants were lower in FMF patients during an acute attack than in the attack-free period. Serum lipid hydroperoxide levels were significantly higher, and antioxidants were significantly lower in patients with the M694V homozygous mutations than the other genotypes. Our data imply that higher serum lipid hydroperoxide and lower antioxidant enzyme activities in FMF may indicate inflammation-related 'oxidative stress'. Our findings also raise interesting questions on oxidative stress and its associations with pyrine mutations in FMF and awaits further investigations.en_US
dc.identifier.citationÇelik, S., Öktenli, Ç., Terekeci, M. H., İpçioğlu, O., Sanisoğlu, Y. S., Sayan, Ö., Yeşilova, Z., Yıldız, O., Tunca, Y. ve Nalbant, S. (2010). Blood oxidative stres biomarkers in patients with Familial Mediterranean Fever (FMF). Aktuelle Rheumatologie, Thieme Publishing Group. 35(6), s. 382-385.en_US
dc.identifier.endpage385en_US
dc.identifier.issn0341-051X
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage382en_US
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0029-1242797#A00128-3
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3500
dc.identifier.volume35en_US
dc.language.isoenen_US
dc.publisherThieme Publishing Groupen_US
dc.relation.ispartofAktuelle Rheumatologieen_US
dc.relation.isversionof10.1055 / s-0029-1242797en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00156
dc.subjectfamilial mediterranean feveren_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectcatalaseen_US
dc.subjectlipid hydroperoxideen_US
dc.subjectpyrine mutationsen_US
dc.titleBlood oxidative stres biomarkers in patients with Familial Mediterranean Fever (FMF)en_US
dc.typeArticle
dspace.entity.typePublication

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