Does erythropoietin affect motility of spermatozoa?

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dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorTuğ, Niyazi
dc.contributor.authorAltunkaynak, Muhammed Eyüp
dc.contributor.authorAktaş, Ranan Gülhan
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorCam, Cetin
dc.contributor.authorKarateke, Ateş
dc.date.accessioned2024-07-12T21:02:00Z
dc.date.available2024-07-12T21:02:00Z
dc.date.issued2010en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIntroduction Erythropoietin, which is a hematopoietic growth factor, has been found to play a role in various physiologic processes within the body including testicular steroidogenesis and spermatogenesis. However, it is not known whether erythropoietin is also essential for the normal physiology of mature sperm cells. In this study, the effects of recombinant human erythropoietin beta (rEPO) on sperm motility were investigated. Materials and methods Samples of 37 volunteers (with total motile sperm count >5 × 106/ml and a total motility of >50% according to WHO criteria) were collected by masturbation following a 3–5 days period of abstinence. After morphometric analysis before and just after washing, samples were either used as control or treated with rEPO at concentrations of 0.1, 1, 10 or 100 mIU/ml, respectively. Control and treated tubes were incubated for 4 h at 37°C. Results Total motility, total progressive motility, slow forward and nonmotile sperm counts of 1, 10 and 100 mIU/ml rEPO groups were significantly improved. This effect was dose independent. Conclusion No significant effect was found at 0.1 mIU/ml concentration. These results suggest that supplementation of media used for sperm preparation techniques with erythropoietin might be beneficial. Further studies are needed to clarify the mechanism of action of erythropoietin on mature sperm cells.en_US
dc.identifier.citationTug, N., Altunkaynak, M.E., Aktas, R.G. et al.(2010). Does erythropoietin affect motility of spermatozoa?. Archives of Gynecology and Obstetrics, Springerlink. 281, s. 933-938.en_US
dc.identifier.endpage938en_US
dc.identifier.issn1432-0711
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage933en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s00404-009-1289-4
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3559
dc.identifier.volume281en_US
dc.institutionauthorAktaş, Ranan Gülhan
dc.language.isoenen_US
dc.publisherSpringerlinken_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.isversionof10.1007/s00404-009-1289-4en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00340
dc.titleDoes erythropoietin affect motility of spermatozoa?en_US
dc.typeArticle
dspace.entity.typePublication

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