Histologic Changes in Eustachian Tube Mucosa of Rats After Exposure to Gastric Reflux

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dc.authorid0000-0002-6197-7654en_US
dc.contributor.authorYazici, Zahide Mine
dc.contributor.authorSari, Murat
dc.contributor.authorUneri, Cuneyd
dc.contributor.authorMidi, Ahmet
dc.contributor.authorTugtepe, Halil
dc.date.accessioned2024-07-12T21:51:43Z
dc.date.available2024-07-12T21:51:43Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: Reflux is thought to be a risk factor for middle ear disease, but the mechanism underlying this relationship is unclear. In this study, we evaluated the effects of reflux on the eustachian tube (ET) mucosa. Materials and Methods: Twenty-two healthy 150 to 220 g Wistar rats with normal middle ears were used. The animals were divided into three groups according to exposure time: 1-, 3-, and 12-week exposures. Four rats were used as a control group. An experimental model of gastroesophageal reflux was induced under general anthesia. After exposure, the animals were sacrificed, and cross sections of the ETs were prepared. The histologic changes in the ET mucosa were observed under a light microscope. Results: The density of goblet cells, numbers of lymphocytes, polymorphonuclear leukocytes, and eosinophils, subepithelial edema, subepithelial vasodilatation, subepithelial gland formation, and intraepithelial gland formation were compared among the groups; The goblet cell density and numbers of lymphocytes and polymorphonuclear leukocytes were significantly higher in the three exposure groups compared with the control group. Conclusion: Nasopharyngeal exposure to experimental reflux alters the ET mucosa histopathology, which suggests that gastroesophageal reflux has a role in ET dysfunction.en_US
dc.identifier.doi10.1097/MLG.0b013e318164d0c0
dc.identifier.endpage853en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue5en_US
dc.identifier.pmid18300701en_US
dc.identifier.scopus2-s2.0-43049121360en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage849en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MLG.0b013e318164d0c0
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8309
dc.identifier.volume118en_US
dc.identifier.wosWOS:000260662100016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofLARYNGOSCOPEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02183
dc.subjectGastroesophageal refluxen_US
dc.subjecteustachian tubeen_US
dc.subjectgoblet cellsen_US
dc.titleHistologic Changes in Eustachian Tube Mucosa of Rats After Exposure to Gastric Refluxen_US
dc.typeArticle
dspace.entity.typePublication

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