Can Neutrophil Lymphocyte Ratio Predict the Likelihood of Suicide in Patients with Major Depression?

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dc.contributor.authorMeydaneri, Gozde Gundogdu
dc.contributor.authorMeydaneri, Sertac
dc.date.accessioned2024-07-12T21:46:03Z
dc.date.available2024-07-12T21:46:03Z
dc.date.issued2018en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground Neutrophil lymphocyte rate (NLR), platelet lymphocyte rate (PLR), and systemic immune inflammatory index (SIII) are rates obtained from hemogram parameters, and they are biomarkers used for the diagnoses of many diseases and their severity, and prediction of disease. In addition to the NLR, PLR, and SIII, platelets, plateletcrit (PCT), and platelet distribution width (PDW), which are platelet indices, are also investigated as biomarkers in many diseases. There are limited studies on the use of hemogram derivates (NLR, PLR, and SIII) in the diagnosis and severity determination of psychiatric disorders. Objectives In this study, we aimed to investigate the effect of biomarkers and the proportions of NLR, PLR, and SIII, which are obtained from hemogram parameters, to distinguish or predict the patients with major depression who are likely to commit suicide. Materials and methods In this retrospective study, the files of patients referred to an educational research emergency and psychiatric outpatient clinic between June 2017 and December 2017 were evaluated. Patients who had been referred to the emergency polyclinic because of suicide attempts and those with major depression diagnosed at a psychiatric clinic were evaluated in this study. All hemogram evaluations were performed using the Sysmex XT-20001 Automated Hematology Analyzer (GMI, MN, USA). Results Twenty-seven suicide patients and 26 major depression groups meeting the study acceptance criteria were included in the evaluation. Of these patients, 40 were female and 13 were male. There was no difference between the groups in terms of age, body mass index, and complete blood count (CBC) parameters such as white blood cell (WBC), neutrophil count, lymphocyte count, eosinophil count, monocyte count, platelet indices, and NLR, PLR, SIII, which were obtained from the hemogram. Conclusion We found that the neutrophil to lymphocyte ratio and other biomarkers obtained from hemograms were higher in patients with major depression than those who had suicide attempts, but we found that this was not statistically significant.en_US
dc.identifier.doi10.7759/cureus.2510
dc.identifier.issn2168-8184
dc.identifier.issue4en_US
dc.identifier.pmid29930888en_US
dc.identifier.urihttps://dx.doi.org/10.7759/cureus.2510
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7879
dc.identifier.volume10en_US
dc.identifier.wosWOS:000450939400108en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCUREUS INCen_US
dc.relation.ispartofCUREUSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00573
dc.subjectsuicideen_US
dc.subjectneutrophil/lymphocyte ratioen_US
dc.subjectdepressionen_US
dc.titleCan Neutrophil Lymphocyte Ratio Predict the Likelihood of Suicide in Patients with Major Depression?en_US
dc.typeArticle
dspace.entity.typePublication

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