Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect?

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Tarih

2005

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

SAGE PUBLICATIONS LTD

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Araştırma projeleri

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Özet

Comorbid alcohol dependence is common in patients with schizophrenia and is associated with a variety of serious adverse consequences. Although case reports exist concerning the positive impact of lamotrigine addition on clozapine treatment in resistant schizophrenia, a review of the literature fails to document any evidence regarding a combination of the two in the treatment of patients with schizophrenia and comorbid alcohol dependence. In the present study, we present three cases in which patients with resistant schizophrenia and comorbid alcohol use disorder were given lamotrigine to augment clozapine. Our findings suggest that clozapine plus lamotrigine may be helpful inreducing alcohol consumption and craving among patients with schizophrenia and comorbid alcohol dependence.

Açıklama

Anahtar Kelimeler

alcohol dependence, clozapine, craving, lamotrigine, schizophrenia

Kaynak

JOURNAL OF PSYCHOPHARMACOLOGY

WoS Q Değeri

Q1

Scopus Q Değeri

Q1

Cilt

19

Sayı

3

Künye