Comparison of hemodynamic and neuroendocrine changes during total intravenous anesthesia and inhalation anesthesia
dc.authorid | 0000-0002-5731-2801 | en_US |
dc.contributor.author | Özkan, Sezai | |
dc.contributor.author | Usyılmaz, Serdar | |
dc.contributor.author | Çankır, Zeki | |
dc.contributor.author | Cebeci, Bekir Sıtkı | |
dc.contributor.author | Gökben, Merih | |
dc.date.accessioned | 2024-07-12T21:03:10Z | |
dc.date.available | 2024-07-12T21:03:10Z | |
dc.date.issued | 2001 | en_US |
dc.department | Fakülteler, Tıp Fakültesi | en_US |
dc.description.abstract | Background: Various aspects of anesthesia and surgery cause stress-induced endocrine and metabolic changes in organisms due to stimulation of the sympathoadrenergic system. Intravenous and inhalation anesthetic agents alter endocrine and metabolic responses to surgical stimuli. Objective: The objective of this study was to compare the effects of 2 anesthesia methods on patient response to surgical stress. Three components of general anesthesia were involved: hypnosis, analgesia, and muscle relaxation. Methods: Patients were randomly assigned to 1 of 3 groups: Group I received total intravenous anesthesia (TIVA) using propofol and alfentanil. Group II received inhalation anesthesia and was divided into 2 subgroups: group IIA received isoflurane, and group IIB received sevoflurane. Patients from all 3 groups underwent assessment of hemodynamic variables (heart rate, systolic blood pressure [SBP], and diastolic blood pressure [DBP]) and endocrinologic variables (plasma levels of blood glucose, C peptide, insulin, catecholamines [epinephrine, norepinephrine], and cortisol). Results: Sixty patients were enrolled in the study and assigned to 1 of the 3 groups (20 per group). Heart rate decreased significantly (P < 0.05) after induction and remained lower than the preinduction value throughout surgery in the TIVA group. Significant increases in heart rate occurred in both inhalation anesthesia groups: after intubation (P < 0.01) and after extubation (P < 0.05) in the isoflurane group; after induction, intubation, and extubation (P < 0.05) in the sevoflurane group. SBP decreased significantly in the TIVA group (P < 0.01 after induction and P < 0.05 thereafter); significant increases (P < 0.05) were seen after intubation and after extubation in both inhalation anesthesia groups. DBP decreased (P < 0.05) after intubation in the TIVA group and increased in the isoflurane group (P < 0.01 after intubation and incision, P < 0.05 after extubation). At the first intraoperative hour, significant increases compared with preinduction values (P < 0.05) were observed in C peptide and insulin levels in the TIVA group, epinephrine in the isoflurane group, and blood glucose and norepinephrine in both inhalation anesthesia groups. Significant decreases (P < 0.05) were found in C peptide and insulin levels in the 2 inhalation anesthesia groups. Measurements taken at the second postoperative hour and compared with preinduction values revealed significant increases (P < 0.05) in C peptide in all groups, norepinephrine in the TIVA group, and insulin and cortisol in the 2 inhalation anesthesia groups. Conclusions: Based on our results, we concluded that hemodynamic and neuroendocrine responses to surgical stress are better controlled with TIVA compared with inhalation anesthesia. | en_US |
dc.identifier.citation | Özkan, S., Cingözbay, B. Y., Usyılmaz, S., Çankır, Z., Cebeci, B. S. ve Gökben, M. (2001). Comparison of hemodynamic and neuroendocrine changes during total intravenous anesthesia and inhalation anesthesia. Current therapeutic research, Elsevier. 62(2), s. 142-152. | en_US |
dc.identifier.endpage | 152 | en_US |
dc.identifier.issn | 0011-393X | |
dc.identifier.issue | 2 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 142 | en_US |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0011393X01800230 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12415/3640 | |
dc.identifier.volume | 62 | en_US |
dc.institutionauthor | Cingözbay, Bekir Yılmaz | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Current therapeutic research | en_US |
dc.relation.isversionof | 10.1016/S0011-393X(01)80023-0 | en_US |
dc.relation.publicationcategory | Ulusal Hakemli Dergide Makale - Kurum Öğretim Elemanı | en_US |
dc.rights | CC0 1.0 Universal | * |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.snmz | KY00595 | |
dc.subject | total intravenous anesthesia | en_US |
dc.subject | isoflurane | en_US |
dc.subject | sevoflurane | en_US |
dc.subject | cortisol | en_US |
dc.subject | epinephrine | en_US |
dc.title | Comparison of hemodynamic and neuroendocrine changes during total intravenous anesthesia and inhalation anesthesia | en_US |
dc.type | Article | |
dspace.entity.type | Publication |