Hippocampus and amygdalar volumes in patients with refractory obsessive-compulsive disorder

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dc.contributor.authorAtmaca, Murad
dc.contributor.authorYildirim, Hanefi
dc.contributor.authorOzdemir, Huseyin
dc.contributor.authorOzler, Sinan
dc.contributor.authorKara, Bilge
dc.contributor.authorOzler, Zuhal
dc.contributor.authorKanmaz, Ebru
dc.contributor.authorMermi, Osman
dc.contributor.authorTezcan, Ertan
dc.date.accessioned2024-07-12T21:58:19Z
dc.date.available2024-07-12T21:58:19Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractFunctional and structural neuroimaging studies have implicated the hippocampus-amygdala complex in the pathophysiology of obsessive-compulsive disorder (OCD), although no consensus has been established. These brain regions have not been investigated in refractory OCD patients. Volumes of the hippocampus, and amygdala were measured by magnetic resonance imaging (MRI) in a sample of 14 refractory OCD patients and 14 healthy comparison subjects. The mean left and right hippocampal and amygdala volumes of the patients were smaller than those of the healthy controls. OCD severity was not correlated with amygdala volumes but was related to the left hippocampus. Duration of illness was correlated with both hippocampus and left amygdala. Our findings suggest that hippocampus and amygdalar abnormalities can be considered in refractoriness to OCD. (C) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2008.04.002
dc.identifier.endpage1286en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue5en_US
dc.identifier.pmid18485556en_US
dc.identifier.scopus2-s2.0-49849094880en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1283en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.pnpbp.2008.04.002
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8771
dc.identifier.volume32en_US
dc.identifier.wosWOS:000258213200027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRYen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY09287
dc.subjectMRIen_US
dc.subjecthippocampusen_US
dc.subjectamygdalaen_US
dc.subjectvolumetricen_US
dc.titleHippocampus and amygdalar volumes in patients with refractory obsessive-compulsive disorderen_US
dc.typeReview
dspace.entity.typePublication

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