The efficacy of donepezil in two cases with alcohol induced Korsakoff's Syndrome

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dc.contributor.authorBinbay, Zerrin
dc.contributor.authorMirsal, Hasan
dc.contributor.authorKalyoncu, Oe. Ayhan
dc.contributor.authorPektas, Oezkan
dc.contributor.authorGenc, Yasin
dc.contributor.authorUensalan, Nasibe
dc.contributor.authorBeyazyuerek, Mansur
dc.date.accessioned2024-07-12T21:51:38Z
dc.date.available2024-07-12T21:51:38Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAccording to DSM-IV, amnestic disorder, known as "Alcohol Induced Persisting Amnestic Disorder" and classically known as "Wernicke Encephalopathy' or "Korsakoffs Syndrome" is an important clinical condition because of the poor nutrition most commonly associated with chronic alcohol abuse. Donepezil, a primarily peripheric and central acetyl cholinesterase inhibitor, increases acetylcholine concentration in cholinergic synapses and can improve symptoms of amnesia. In this article, we present two cases with "Alcohol Induced Persisting Amnestic Disorder" and depressive disorder treated by donepezil, in which improvement in cognitive functions have been shown. The patients were followed up with the Hamilton Depression Rating Scale (HDRS), and Mini Mental State Examination (MMSE) and clinical observation. In both of the cases, donepezil was added to the anti-depressant drug treatment and improvement in cognitive function was noted together with improvement in depressive symptoms. In the first case standard MMSE score increased by 18 points to 26; in the second case by 16 points to 28. Large-scale prospective, double-blind, placebo -controlled studies are needed to confirm the efficacy of Donepezil in Alcohol Induced Persisting Amnestic Disorder.en_US
dc.identifier.endpage49en_US
dc.identifier.issn1017-7833
dc.identifier.issue1en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8296
dc.identifier.volume18en_US
dc.identifier.wosWOS:000257876100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.language.isotren_US
dc.publisherKURE ILETISIM GRUBU A Sen_US
dc.relation.ispartofKLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02133
dc.subjectKorsakofrs Syndromeen_US
dc.subjectdonepezilen_US
dc.subjectamnestic disorderen_US
dc.subjectthiamine deficiencyen_US
dc.subjectalcohol dependenceen_US
dc.titleThe efficacy of donepezil in two cases with alcohol induced Korsakoff's Syndromeen_US
dc.typeArticle
dspace.entity.typePublication

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