The efficacy of donepezil in two cases with alcohol induced Korsakoff's Syndrome
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
KURE ILETISIM GRUBU A S
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
According to DSM-IV, amnestic disorder, known as "Alcohol Induced Persisting Amnestic Disorder" and classically known as "Wernicke Encephalopathy' or "Korsakoffs Syndrome" is an important clinical condition because of the poor nutrition most commonly associated with chronic alcohol abuse. Donepezil, a primarily peripheric and central acetyl cholinesterase inhibitor, increases acetylcholine concentration in cholinergic synapses and can improve symptoms of amnesia. In this article, we present two cases with "Alcohol Induced Persisting Amnestic Disorder" and depressive disorder treated by donepezil, in which improvement in cognitive functions have been shown. The patients were followed up with the Hamilton Depression Rating Scale (HDRS), and Mini Mental State Examination (MMSE) and clinical observation. In both of the cases, donepezil was added to the anti-depressant drug treatment and improvement in cognitive function was noted together with improvement in depressive symptoms. In the first case standard MMSE score increased by 18 points to 26; in the second case by 16 points to 28. Large-scale prospective, double-blind, placebo -controlled studies are needed to confirm the efficacy of Donepezil in Alcohol Induced Persisting Amnestic Disorder.
Açıklama
Anahtar Kelimeler
Korsakofrs Syndrome, donepezil, amnestic disorder, thiamine deficiency, alcohol dependence
Kaynak
KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
18
Sayı
1
