Omeprazole is more effective than famotidine for preventing acute gastritis in rats

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dc.contributor.authorTopaloglu, U
dc.contributor.authorMuftuoglu, T
dc.contributor.authorAkturk, Z
dc.contributor.authorEkinci, H
dc.contributor.authorPeker, O
dc.contributor.authorUnalmiser, S
dc.date.accessioned2024-07-12T21:53:24Z
dc.date.available2024-07-12T21:53:24Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractPurpose. Acute gastric mucosal lesions, which can develop within a few hours after polytrauma, shock, major operations, central nervous system lesions, or severe infection, cause about 33% of cases of gastrointestinal bleeding. We analyzed and compared the effectiveness of famotidine and omeprazole on acute gastric mucosal lesions. Methods. Thirty male albino Wistar rats were given ketalar anesthesia after 12 h fasting, then immobilized and exposed to stress according to Brodie's protocol, without restricting their respiration. We divided the rats into three groups of ten according to whether they were given famotidine, omeprazole, or normal saline (control group). All rats were ulcer-indexed according to the diameter of their ulcers. The stomach contents were aspirated for acid output and pH analysis, and sent to the laboratory. The total number of mast cells was also counted. Results. Omeprazole was more effective than famotidine in keeping gastric pH high and lowering the total gastric acid output. Lower ulcer indexes in acute gastric mucosal erosions and better protected mucosal integrity were found in the omeprazole-treated rats. Conclusion. Omeprazole prevents acute gastric mucosal erosions in rats more effectively than famotidine.en_US
dc.identifier.doi10.1007/s00595-004-2800-y
dc.identifier.endpage694en_US
dc.identifier.issn0941-1291
dc.identifier.issue8en_US
dc.identifier.pmid15290400en_US
dc.identifier.scopus2-s2.0-4043096315en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage690en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00595-004-2800-y
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8495
dc.identifier.volume34en_US
dc.identifier.wosWOS:000223021400010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofSURGERY TODAYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03454
dc.subjectgastric mucosal lesionen_US
dc.subjectgastric acid outputen_US
dc.subjectPHen_US
dc.subjectfamotidineen_US
dc.subjectomeprazoleen_US
dc.titleOmeprazole is more effective than famotidine for preventing acute gastritis in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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