Effect of an oral anxiolytic medication and heart rate variability on image quality of 64-slice MDCT coronary angiography

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dc.authorid0000-0001-6945-0745en_US
dc.authorid0000-0002-5539-2502en_US
dc.contributor.authorCubuk, R.
dc.contributor.authorTasali, N.
dc.contributor.authorYilmazer, S.
dc.contributor.authorGokalp, P.
dc.contributor.authorCelik, L.
dc.contributor.authorDagdeviren, B.
dc.contributor.authorGuney, S.
dc.date.accessioned2024-07-12T21:53:02Z
dc.date.available2024-07-12T21:53:02Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe aim of the study was to investigate the relationship between image quality in 64-slice multidetector computed tomography (MDCT) and patients' preimaging anxiety status and heart rate variability (HRV), and to evaluate the efficacy of an orally administered anxiolytic medication on HRV and image quality. Sixty patients [14 women, 46 men; mean age 52.53 +/- 10.55 (SD), range 33-78 years] were studied. Anxiety levels were assessed with the State-Trait Anxiety Inventory 60 min before the procedure. The participating patients were randomly assigned to one of the two study groups: a control group (no medication administered for anxiety reduction) and an anxiolytic medication group, with 30 patients in each group. The presence of motion artefacts and image quality for each coronary artery segment were evaluated using a four-point grading system. To estimate HRV, the duration of each heartbeat during MDCT data acquisition was measured in each patient. A moderate correlation was found between HRV during MDCT scanning and the mean image quality for all coronary segments (r=0.47, p < 0.01). There was an association between HRV and state anxiety scores in all cases (r=0.370, p < 0.01). HRV in the patients who received alprazolam was statistically significantly lower than in controls (p < 0.05). The average image quality in patients who used alprazolam was also statistically significantly higher than in controls (p < 0.05). The most important finding in our study is that oral premedication to reduce anxiety is also effective in decreasing HRV and improves image quality. Therefore, we suggest that using alprazolam in addition to a beta-blocker may improve image quality in patients undergoing MDCT coronary angiography (MDCT-CA). Anxiolytic usage may improve image quality by lowering the HRV in selected cases where administration of a beta-blocker is contraindicated. We also suggest that further studies in larger series are required to validate this finding.en_US
dc.identifier.doi10.1007/s11547-010-0581-5
dc.identifier.endpage55en_US
dc.identifier.issn0033-8362
dc.identifier.issue1en_US
dc.identifier.pmid20852958en_US
dc.identifier.scopus2-s2.0-79952313459en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11547-010-0581-5
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8451
dc.identifier.volume116en_US
dc.identifier.wosWOS:000287507400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofRADIOLOGIA MEDICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03329
dc.subjectMultidetector computed tomographyen_US
dc.subjectCoronary angiographyen_US
dc.subjectHeart rateen_US
dc.subjectBenzodiazepinesen_US
dc.subjectPremedicationen_US
dc.titleEffect of an oral anxiolytic medication and heart rate variability on image quality of 64-slice MDCT coronary angiographyen_US
dc.typeArticle
dspace.entity.typePublication

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