Etiology of serum CA-125 in patients with endometriosis treated with a gonadotrophin-releasing hormone agonist (Buserelin)
Küçük Resim Yok
Tarih
1994
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Karger Publishing
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Fifty-six patients with pelvic endometriosis were treated with a buserelin dosage of 200 µg/day s.c. for 6 months. Scoring of the American Fertility Society (AFS) for endometriosis was performed by laparoscopy in all cases before and at the end of therapy. Serum CA-125 and estradiol levels were determined before the treatment, and monthly during therapy and follow-up (6 months; respectively). A slight positive correlation was found between serum CA-125 concentrations before treatment and AFS scores for adhesions only. Before treatment, serum CA-125 values also correlated slightly with total AFS scores of patients with adhesions. At the end of the 6-month therapy, no correlation was found between CA-125 concentrations and second-look AFS scores for implants and/or adhesions. Serum CA-125 and estradiol values were closely parallel to each other during and after therapy with the gonadotrophin-releasing hormone agonist buserelin. In conclusion, (1) adhesions may play a role in the elevation of serum CA-125 levels in endometriosis, and (2) a significant decrease in serum CA-125 values during the buserelin therapy may result from a rather different mechanism, such as ovarian suppression, other than the therapeutic effect of this agent.
Açıklama
Anahtar Kelimeler
Endometriosis, CA-125, Buserelin
Kaynak
Gynecologic and Obstetric Investigation
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
38
Sayı
4
Künye
Çetin, T., Vardar, M. A., Demir, C. ve Burgut, H. R. (1994). Etiology of serum CA-125 in patients with endometriosis treated with a gonadotrophin-releasing hormone agonist (Buserelin). Karger Publishing. 38(4), s. 294-252.
