The Effect of Vitamin C on Ischemia Reperfusion Injury Because of Prolonged Tourniquet Application With Reperfusion Intervals

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dc.authorid0000-0003-0469-2801en_US
dc.contributor.authorUlug, Burcak Tumerdem
dc.contributor.authorAksungar, Fehime Benli
dc.contributor.authorMete, Ozgur
dc.contributor.authorTekeli, Fatma
dc.contributor.authorMutlu, Nilgun
dc.contributor.authorCalik, Burcu
dc.date.accessioned2024-07-12T21:45:01Z
dc.date.available2024-07-12T21:45:01Z
dc.date.issued2009en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractWe examined the effect of vitamin Con muscle injury distal to the tourniquet which was applied for 4 hours with 10- and 20-minute reperfusion intervals after 2 hours of tourniquet. Sixty-four Sprague-Dawley rats were allocated to 4 randomized groups. After 2 hours tourniquet, 10- and 20-minutes of reperfusion were allowed to half of each group respectively. Afterward an additional 2 hours compression was applied. Except the control group the animals received vitamin C intravenously, before the first tourniquet in Group 1, at the reperfusion interval in Group 11, and at both times in Group III. Malondialdehyde levels were measured in blood and the tibialis anterior muscle. The muscle was histopathologically examined. The data was evaluated statistically. The effects of timing and the dose of vitamin C on ischemia reperfusion injury remain controversial and there was no statistical difference between 10- and 20-minute reperfusion intervals. But the blood malondialdehyde levels showed that vitamin C has a positive effect on the muscle injury caused by ischemia-reperfusion.en_US
dc.identifier.doi10.1097/SAP.0b013e318184ab74
dc.identifier.endpage199en_US
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue2en_US
dc.identifier.pmid19158533en_US
dc.identifier.scopus2-s2.0-65949124665en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage194en_US
dc.identifier.urihttps://dx.doi.org/10.1097/SAP.0b013e318184ab74
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7774
dc.identifier.volume62en_US
dc.identifier.wosWOS:000262680700020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofANNALS OF PLASTIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00269
dc.subjectischemia reperfusion injuryen_US
dc.subjecttourniqueten_US
dc.subjectvitamin Cen_US
dc.titleThe Effect of Vitamin C on Ischemia Reperfusion Injury Because of Prolonged Tourniquet Application With Reperfusion Intervalsen_US
dc.typeArticle
dspace.entity.typePublication

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