Long-term chronic caloric restriction alters miRNA profiles in the brain of ageing mice

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dc.authoridÖzorhan, Ümit/0000-0002-7661-2818en_US
dc.authoridBayrak, Omer Faruk/0000-0001-7562-6604en_US
dc.authoridYılmaz, Bayram/0000-0002-2674-6535en_US
dc.authoridThomas, Pınar Buket/0000-0001-7627-0291en_US
dc.authoridTuna, Bilge Güvenc/0000-0003-1348-1336en_US
dc.authoridCicekdal, Münevver Burcu/0000-0002-1986-0815en_US
dc.authoridDOGAN, SONER/0000-0002-7762-8109en_US
dc.contributor.authorÖzorhan, Ümit
dc.contributor.authorTuna, Bilge G.
dc.contributor.authorCicekdal, Münevver B.
dc.contributor.authorKuskucu, Ayşegül
dc.contributor.authorBayrak, Omer F.
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorDemirel, Pınar B.
dc.date.accessioned2024-07-12T21:37:44Z
dc.date.available2024-07-12T21:37:44Z
dc.date.issued2022en_US
dc.department[Belirlenecek]en_US
dc.description.abstractCalorie restriction (CR) has been shown to be one of the most effective methods in alleviating the effects of ageing and age-related diseases. Although the protective effects of CR have been reported, the exact molecular mechanism still needs to be clarified. This study aims to determine differentially expressed (DE) miRNAs and altered gene pathways due to long-term chronic (CCR) and intermittent (ICR) CR in the brain of mice to understand the preventive roles of miRNAs resulting from long-term CR. Ten weeks old mice were enrolled into three different dietary groups; ad libitum, CCR or ICR, and fed until 82 weeks of age. miRNAs were analysed using GeneChip 4.1 microarray and the target of DE miRNAs was determined using miRNA target databases. Out of a total 3,163 analysed miRNAs, 55 of them were differentially expressed either by different CR protocols or by ageing. Brain samples from the CCR group had increased expression levels of mmu-miR-713 while decreasing expression levels of mmu-miR-184-3p and mmu-miR-351-5p compared to the other dietary groups. Also, current results indicated that CCR showed better preventive effects than that of ICR. Thus, CCR may perform its protective effects by modulating these specific miRNAs since they are shown to play roles in neurogenesis, chromatin and histone regulation. In conclusion, these three miRNAs could be potential targets for neurodegenerative and ageing-related diseases and may play important roles in the protective effects of CR in the brain.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [119S238]en_US
dc.description.sponsorshipThis work was financially supported by Scientific and Technological Research Council of Turkey (TUBITAK grant #119S238). No other support from any commercial or not-forprofit sectors.en_US
dc.identifier.doi10.1017/S0007114521001239
dc.identifier.endpage652en_US
dc.identifier.issn0007-1145
dc.identifier.issn1475-2662
dc.identifier.issue5en_US
dc.identifier.pmid33823947en_US
dc.identifier.scopus2-s2.0-85103849082en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage641en_US
dc.identifier.urihttps://doi.org/10.1017/S0007114521001239
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6914
dc.identifier.volume127en_US
dc.identifier.wosWOS:000744693400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofBritish Journal of Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04256
dc.subjectIntermittent Calorie Restrictionen_US
dc.subjectMirnaen_US
dc.subjectAgeingen_US
dc.subjectNeurodegenerationen_US
dc.subjectNeurogenesisen_US
dc.subjectBrainen_US
dc.titleLong-term chronic caloric restriction alters miRNA profiles in the brain of ageing miceen_US
dc.typeArticle
dspace.entity.typePublication

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