Lithium excessively enhances event related beta oscillations in patients with bipolar disorder

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dc.authorid0000-0002-8514-0576en_US
dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0003-0150-5476en_US
dc.contributor.authorAtagun, Murat Ilhan
dc.contributor.authorGuntekin, Bahar
dc.contributor.authorTan, Devran
dc.contributor.authorTulay, Emine Elif
dc.contributor.authorBasar, Erol
dc.date.accessioned2024-07-12T21:50:06Z
dc.date.available2024-07-12T21:50:06Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Previous resting-state electroencephalography studies have consistently shown that lithium enhances delta and theta oscillations in default mode networks. Cognitive task based networks differ horn resting-state networks and this is the first study to investigate effects or lithium on evoked and event-related beta oscillatory responses of patients with bipolar disorder. Methods: The study included 16 euthymic patients with bipolar disorder on lithium monotherapy, 22 euthymic medication-free patients with bipolar disorder and 21 healthy participants. The maximum peak-to-peak amplitudes were measured for each subject's averaged beta responses (14-28 Hz) in the 0-300 ms time window. Auditory simple and oddball paradigm were presented to obtain evoked and event-related beta oscillatory responses. Results: There were significant differences in beta oscillatory responses between groups (p=0.010). Repeated measures ANOVA revealed location (p=0.007), laterality X group (p=0.043) and stimulus X location (p=0.013) type effects. Serum lithium levels were correlated with beta responses. Limitations: The lithium group had higher number of previous episodes, suggesting that patients of the lithium were more severe cases than patients of the medication-free group. Discussion: Lithium stimulates neuroplastic cascades and beta oscillations become prominent during neuroplastic changes. Excessively enhanced beta oscillatory responses in the lithium-treated patients may be indicative of excessive activation of the neuron groups of the certain cognitive networks and dysfunctional GABAergic modulation during cognitive activity. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipIstanbul Kultur University; Bakirkoy Research and Training Hospitalen_US
dc.description.sponsorshipIstanbul Kultur University has funded and Bakirkoy Research and Training Hospital has supported the study.en_US
dc.identifier.doi10.1016/j.jad.2014.08.024
dc.identifier.endpage65en_US
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.pmid25233240en_US
dc.identifier.scopus2-s2.0-84907943580en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jad.2014.08.024
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8131
dc.identifier.volume170en_US
dc.identifier.wosWOS:000344226700010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF AFFECTIVE DISORDERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01784
dc.subjectBipolar disorderen_US
dc.subjectBrain oscillationsen_US
dc.subjectEvent-related oscillationsen_US
dc.subjectLithiumen_US
dc.subjectEuthymiaen_US
dc.titleLithium excessively enhances event related beta oscillations in patients with bipolar disorderen_US
dc.typeArticle
dspace.entity.typePublication

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