Does a relationship exist between neutrophil-to-lymphocyte ratio, platelet-tolymphocyte ratio and sarcopenia in Alzheimer's disease?

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dc.authorid0000-0003-3868-3137en_US
dc.authorid000-0003-2016-9965en_US
dc.authorid0000-0001-5953-4240en_US
dc.authorid0000-0002-2887-9235en_US
dc.contributor.authorÇınar, Nigün
dc.contributor.authorŞahin, Şevki
dc.contributor.authorAteş, Miruna Florentina
dc.contributor.authorKarşıdağ, Sibel
dc.date.accessioned2024-07-12T21:01:19Z
dc.date.available2024-07-12T21:01:19Z
dc.date.issued2019en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractAim: The prevalence of sarcopenia is higher in Alzheimer’s disease (AD) when compared with subjects with normal cognition. Easy-to-use screening tools can make it easier to reach the diagnosis. We aimed to evaluate inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in AD cases with or without sarpcopenia. Materials and Methods: Seventy-four possible AD cases who were resident in nursing home were included in to cross-sectional study. Body mass index (BMI), fat mass index (FMI), muscle mass index (MMI), and fat free mass index (FFMI) were assessed with electronic body composition analyzer. Short physical performance battery (SPPB), mini-nutritional assessment (MNA) and hand grip strength test were used for mobile patients. Calf circumference and mid-arm circumference were used for immobile patients. A diagnosis of sarcopenia was established according to the ‘European Working Group on Sarcopenia in Older People’ criterias. NLR and PLR were calculated as the ratio of the neutrophil count to lymphocyte count, and platelet count to lymphocyte count, respectively. Findings of AD cases with and without sarcopenia were compared according to NLR and PLR ratios. Results: The sarcopenia rate was found to be 48%. Significantly higher NLR and PLR values were found in sarcopenic group. NLR were found to be negatively correlated with FFMI, while PLR were found negativeliy correlated with both FFMI and MNA. Conclusion: It was found that NLR and especially PLR values are significantly related to sarcopenia in AD. Evaluation of NLR and PLR may be useful for sarcopenia screening.en_US
dc.identifier.citationÇınar, N., Şahin, Ş., Ateş, M.F. ve Karşıdağ, S. (2019). Does a relationship exist between neutrophil-to-lymphocyte ratio, platelet-tolymphocyte ratio and sarcopenia in Alzheimer's disease?. Advances in Neurology and Neuroscience, Opast Group. 2(1), s. 1-5.en_US
dc.identifier.endpage5en_US
dc.identifier.issn2690-909X
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.opastpublishers.com/table-contents/anns-volume-2-issue-1-year-2019
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3487
dc.identifier.volume2en_US
dc.institutionauthorÇınar, Nilgün
dc.institutionauthorŞahin, Şevki
dc.institutionauthorAteş, Miruna Florentina
dc.institutionauthorKarşıdağ, Sibel
dc.language.isoenen_US
dc.publisherOpast Groupen_US
dc.relation.ispartofAdvances in Neurology and Neuroscienceen_US
dc.relation.isversionof10.33140/AN.02.01.05en_US
dc.relation.publicationcategoryUluslararası Editör Denetimli Dergide Makaleen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00105
dc.subjectMalnutritionen_US
dc.subjectSarcopeniaen_US
dc.subjectAlzheimer’sen_US
dc.subjectInflammationen_US
dc.subjectScreening Testen_US
dc.titleDoes a relationship exist between neutrophil-to-lymphocyte ratio, platelet-tolymphocyte ratio and sarcopenia in Alzheimer's disease?en_US
dc.typeArticle
dspace.entity.typePublication

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