Oxidation scrutiny in persuaded aging and chronological aging at systemic redox homeostasis level

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dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorCebe, Tamer
dc.contributor.authorAtukeren, Pınar
dc.contributor.authorYanar, Karolin
dc.contributor.authorKuruç, Aylin Irmak
dc.contributor.authorOzan, Tuna
dc.contributor.authorKunbaz, Ahmad
dc.contributor.authorSitar, Mustafa Erinç
dc.contributor.authorMirmaroufizibandeh, Reza
dc.contributor.authorAydın, Şeval
dc.contributor.authorÇakatay, Ufuk
dc.date.accessioned2024-07-12T21:03:48Z
dc.date.available2024-07-12T21:03:48Z
dc.date.issued2014en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground The effect of the natural aging process on systemic redox homeostasis is previously documented. However, none of the studies specify the effect of experimental aging on systemic redox homeostasis. The purpose of this study is to clarify the ambiguity raised in preliminary reports as to mimetic aging dependency of the type and magnitude of oxidative damage on constituents of plasma. Methods In the current study, we investigated the interrelationship among various groups of the systemic oxidative damage markers such as protein oxidation products (protein carbonyl groups, protein hydroperoxides, advanced oxidation protein products, protein thiol groups), lipid peroxidation products (malondialdehyde, lipid hydroperoxides, conjugated dienes), glycoxidation adducts (advanced glycation end products), and antioxidant capacity (ferric reducing/antioxidant power, Cu,Zn-superoxide dismutase, total thiol, non-protein thiol). All these markers were measured in plasma of mimetically aged (MA) rats (5-month-old rats subjected to d-galactose-induced experimental aging), naturally aged (NA) rats (24-month-old), and their corresponding young controls (YC) (5 months old). Results and conclusions Our current results show that systemic oxidation markers of the MA group share significant similarities in terms of impaired redox homeostasis with the NA rats and may be considered as a reliable experimental aging model for intravascular aging. Additional methodological studies including d-galactose dosage and application time are warranted to clarify the potential involvement of all these systemic redox variations as mechanistic factors in the development of mimetic aging related intravascular deterioration. Reversing or preventing systemic oxidative damage in experimental and natural aging should therefore be considered the primary target for the development of effective therapeutic strategies to prevent or treat age-related vascular disorders.en_US
dc.identifier.citationCebe, T., Atukeren, P., Yanar, K. vd. (2014). Oxidation scrutiny in persuaded aging and chronological aging at systemic redox homeostasis level. Experimental Gerontology, Elsevier. 57, s. 132-140.en_US
dc.identifier.endpage140en_US
dc.identifier.issn1873-6815
dc.identifier.startpage132en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0531556514001788?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3701
dc.identifier.volume57en_US
dc.institutionauthorSitar, Mustafa Erinç
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofExperimental Gerontologyen_US
dc.relation.isversionof10.1016/j.exger.2014.05.017en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00905
dc.subjectd-Galactoseen_US
dc.subjectNatural agingen_US
dc.subjectProtein oxidationen_US
dc.subjectLipid peroxidationen_US
dc.subjectGlycoxidation adductsen_US
dc.subjectAntioxidant capacityen_US
dc.titleOxidation scrutiny in persuaded aging and chronological aging at systemic redox homeostasis levelen_US
dc.typeArticle
dspace.entity.typePublication

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