The relationship between coronary calcification and the metabolic markers of osteopontin, fetuin-A, and visfatin

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dc.authorid0000-0003-1407-5313en_US
dc.authorid0000-0002-2858-4023en_US
dc.authorid0000-0002-5634-1280en_US
dc.contributor.authorUz, Ömer
dc.contributor.authorKardeşoğlu, Ejder
dc.contributor.authorYiğiner, Ömer
dc.contributor.authorBaş, Serap
dc.contributor.authorİpçioğlu, Osman M.
dc.contributor.authorÖzmen, Namık
dc.contributor.authorAparcı, Mustafa
dc.contributor.authorIşılak, Zafer
dc.contributor.authorCebeci, Bekir Sıtkı
dc.date.accessioned2024-07-12T21:12:24Z
dc.date.available2024-07-12T21:12:24Z
dc.date.issued2009en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjectives: We investigated whether coronary calcification detected by multislice computed tomography (MSCT) was correlated with plasma osteopontin, serum fetuin-A, and visfatin levels. Study design: The study included 64 consecutive patients (51 males, 13 females; mean age 49.5+/-10.9 years; range 33 to 78 years) who underwent MSCT for suspected coronary artery disease. Coronary artery calcification (CAC) scores of the patients were calculated using the Agatston scoring method. Plasma osteopontin, serum fetuin-A, and visfatin levels were measured from fasting blood samples and correlations were sought with calcium scores. Results: Coronary calcification was detected in 32 patients (50%). The mean CAC score was 146.5+/-333.7 Agatston units (AU), indicating an intermediate risk for coronary artery disease. In 10 patients (15.6%), the CAC score exceeded 400 AU. The mean fetuin-A, visfatin, and osteopontin levels were 25.6+/-6.4 ng/ml, 19.7+/-47.2 ng/ml, and 20.4+/-16.1 ng/ml, respectively. Serum visfatin (r=0.15, p=0.37) and fetuin-A (r=0.17, p=0.22) were not correlated with the CAC score, whereas plasma osteopontin level showed a moderate correlation with the CAC score (r=0.35; p=0.008). In ROC analysis, the area under the curve for identification of CAC was greatest for osteopontin (0.741; p=0.004), followed by fetuin-A (0.574; p=0.31), and visfatin (0.580; p=0.27). The cut-off value was 18.45 ng/ml for osteopontin, with a sensitivity of 72% and specificity of 73%. Conclusion: Our results suggest that there might be an association between CAC and plasma osteopontin levels. Research should continue to find out a metabolic parameter that will strongly indicate coronary calcification.en_US
dc.identifier.citationUz, O., Kardeşoğlu, E., Yiğiner, O., Baş, S., Ipçioğlu, O. M., Ozmen, N., Aparci, M., Cingözbay, B. Y., Işilak, Z., & Cebeci, B. S. (2009). The relationship between coronary calcification and the metabolic markers of osteopontin, fetuin-A, and visfatin. Turk Kardiyoloji Dernegi arsivi, Turk Kardiyoloji Dernegi. 37(6), s. 397–402.en_US
dc.identifier.endpage402en_US
dc.identifier.issn1016-5169
dc.identifier.issn1308-4488
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20019453/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4479
dc.identifier.volume37en_US
dc.institutionauthorCingözbay, Bekir Yılmaz
dc.language.isoenen_US
dc.publisherTürk Kardiyoloji Derneğien_US
dc.relation.ispartofTürk Kardiyoloji Derneği Arşivien_US
dc.relation.publicationcategoryUlusal Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY03826
dc.titleThe relationship between coronary calcification and the metabolic markers of osteopontin, fetuin-A, and visfatinen_US
dc.typeArticle
dspace.entity.typePublication

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