Effects of olanzapine on ethanol withdrawal syndrome in rats

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dc.authorid0000-0002-6423-4207en_US
dc.authorid0000-0002-6423-4207en_US
dc.authorid0000-0002-0021-8400en_US
dc.contributor.authorUnsalan, Nasibe
dc.contributor.authorSaglam, Esra
dc.contributor.authorKayir, Hakan
dc.contributor.authorUzbay, Tayfun
dc.date.accessioned2024-07-12T21:46:44Z
dc.date.available2024-07-12T21:46:44Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe present study was designed to investigate the effects of olanzapine, a serotonin-dopamine antagonistic atypical antipsychotic agent, on ethanol withdrawal syndrome in rats. Adult male Wistar rats were subjects. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 21 days. Control rats were pair fed with an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. After 2nd, 4th and 6th h of ethanol withdrawal, rats were observed for 5 min, afterwards withdrawal signs that included locomotor hyperactivity, agitation, stereotyped behavior, tremor, wet dog shakes, abnormal posture and abnormal gait were recorded or rated. Olanzapine (0.5, 1 and 2 mg/kg) and saline were injected to the rats intraperitoneally 30 min before ethanol withdrawal assessment. A second series of injections was also given 30 rain before the 6th-h-observation, and subjects were then tested for audiogenic seizures. Olanzapine (2 mg/kg) produced significant inhibitory effects on stereotyped behaviors and wet dog shakes at the 6th h of ethanol withdrawal. Contrary, the same dose caused some increases in the intensity of posture and gait impairments at the 2nd h of ethanol withdrawal. In addition, that dose was found to be ineffective on agitation, tremor, tail stiffness and audiogenic seizures. Our results suggest that acute olanzapine treatment has beneficial effects on stereotyped behavior and wet dog shakes, but it also has some adverse effects on posture and gait during ethanol withdrawal in rats. Overall, olanzapine does not seem to be an adequate and suitable drug in controlling of ethanol withdrawal syndrome. (c) 2007 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejphar.2007.10.024
dc.identifier.endpage214en_US
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.issue1.Maren_US
dc.identifier.pmid18022155en_US
dc.identifier.scopus2-s2.0-37549016065en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejphar.2007.10.024
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7958
dc.identifier.volume579en_US
dc.identifier.wosWOS:000252979200027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofEUROPEAN JOURNAL OF PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00874
dc.subjectolanzapineen_US
dc.subjectethanol withdrawal syndromeen_US
dc.subjectethanol dependenceen_US
dc.subject(rat)en_US
dc.titleEffects of olanzapine on ethanol withdrawal syndrome in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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