Plasma Ghrelin Levels in Patients with Familial Mediterranean Fever

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dc.contributor.authorPolat, Zulfikar
dc.contributor.authorKilciler, Guldem
dc.contributor.authorOzel, A. Melih
dc.contributor.authorKara, Muammer
dc.contributor.authorKantarcioglu, Murat
dc.contributor.authorUygun, Ahmet
dc.contributor.authorBagci, Sait
dc.date.accessioned2024-07-12T21:46:10Z
dc.date.available2024-07-12T21:46:10Z
dc.date.issued2012en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractFamilial Mediterranean fever (FMF) is an auto-inflammatory disorder characterized by febrile attacks. Increased acute-phase reactants are characteristic during febrile attacks. Ghrelin is a natural G-protein that decreases secretion of pro-inflammatory cytokines and acts as anti-inflammatory agent. The aim of this study was to investigate whether there is any change in ghrelin levels and whether increases in ghrelin levels can be used as a marker in these patients. Thirty-seven male patients and 30 healthy men as a control group were included in the study. Blood samples were obtained for ghrelin measurements both before the attacks (pre-attack period; ghrelin 1 group) and during the attacks (ghrelin 2 group). Samples were kept at -80A degrees C until the analysis was conducted and plasma ghrelin levels were measured using an immune-sorbent assay method. Mean ghrelin levels measured during the attacks were significantly higher (11.01 +/- A 4.78 pg/ml) as compared to pre-attack levels (5.78 +/- A 2.17 pg/ml; p < 0.001). Similarly, mean ghrelin levels measured in FMF patients during an attack were significantly different from that of the control group (6.57 +/- A 4.13 pg/ml; p < 0.001). In this study, high ghrelin levels were measured during attacks in FMF patients. This finding is in line with previous results regarding the fact that inflammatory response arising during an FMF attack is an acute inflammatory event. Our findings suggest that ghrelin levels measured during FMF attacks could be used as a biochemical indicator for the FMF attack in FMF patients and that it could be used for support of the diagnosis of the disease.en_US
dc.identifier.doi10.1007/s10620-012-2049-z
dc.identifier.endpage1663en_US
dc.identifier.issn0163-2116
dc.identifier.issue6en_US
dc.identifier.pmid22297653en_US
dc.identifier.scopus2-s2.0-84864282786en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1660en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10620-012-2049-z
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7901
dc.identifier.volume57en_US
dc.identifier.wosWOS:000304396700032en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofDIGESTIVE DISEASES AND SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00635
dc.subjectGhrelinen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectDiagnosisen_US
dc.subjectPeriodic feveren_US
dc.subjectPeritonitisen_US
dc.titlePlasma Ghrelin Levels in Patients with Familial Mediterranean Feveren_US
dc.typeArticle
dspace.entity.typePublication

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