Hba1c değerlerinin inflamatuar belirteçleri ile ilişkisi
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Türk Klinik Biyokimya Derneği
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Sağlıklı, prediyabetik ve diyabetik gruplarda, HbA1c ile sistemik inflamasyonun yeni belirteçlerinden kabul edilen nötrofil lenfosit oranı (NLO) ve trombosit lenfosit oranı (TLO) ile güçlü inflamasyon belirteçleri olarak kabul gören C Reaktif Protein (CRP) ve sedimantasyon arasındaki ilişkinin araştırılmasıdır. Gereç ve Yöntem: Çalışmamız hastanemize başvuran hasta sonuçlarından retrospektif olarak hazırlanmıştır. Çalışmaya glukoz, HbA1c değerleri, CRP, sedimantasyon, hemogram sonuçları olan hastalar katılmıştır. NLO tam kan sayımındaki nötrofil ve lenfosit mutlak sayısının, TLO ise kan sayımındaki trombosit ve lenfosit sayısının birbirine oranlaması ile bulunmuştur. Hastalar normal (HbA1c <6%), prediyabet (6 6.4%) ve ( ? 6.5%) diyabetik olarak 3 gruba ayrılmıştır. Bulgular: Prediyabetik, diyabetik hastalar ile kontrol grupları arasında glukoz, CRP, sedimantasyon ve nötrofil mutlak sayısı değerlerinde istatistiksel bir fark bulunurken (sırasıyla p<0.001, p<0.05, p<0.05 ve p<0.05) lenfosit mutlak sayısı, trombosit sayısı, NLO ve TLO değerlerinde ise istatistiksel anlamlı bir farklılık bulunamamıştır. Gruplar arasında fark bulunan testler için sağlıklı-prediyabetik grup ele alındığında glukoz, CRP, sedimantasyon ve nötrofil mutlak sayısı için istatistiksel fark bulunurken (p<0.05), sağlıklı-diyabetik grup ele alındığında glukoz ve CRP de istatistiksel anlamlı fark bulunmuştur (p<0.01 ve p<0.05). Prediyabetik-diyabetik grup karşılaştırıldığında ise sadece glukoz değerlerinde gruplar arasında istatistiksel anlamlı fark bulunmuştur (p<0.01). Sonuç: HbA1c değerleri ile inflamasyon belirteçleri olan NLO, TLO, CRP ve sedimantasyon arasındaki ilişki araştırılmış, HbA1c ile NLO, TLO ve sedimantasyon arasında bir ilişki saptanamazken, güçlü inflamatuar belirteç olan CRP ile HbA1c değerleri arasında ilişki saptanmıştır. Bu durum NLO ve TLO değerlerinin klinik kullanımda rutine girebilmesi için daha fazla zaman ve veriye ihtiyaç duyulduğunu göstermektedir.
For this current study, our aims were to investigate the relationships between HbA1c with neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) which are accepted as new markers of systemic inflammation and the relationships between HbA1c with CRP and sedimentation, which are accepted as strong inflammation markers in healthy, prediabetic and diabetic groups. Materials and Method: Our study was conducted retrospectively from the results of patients who applied to our hospital. Patients, who had glucose, HbA1c, CRP, sedimentation and whole blood test results, were recruited for the research. NLR was calculated by the ratio of the absolute numbers of neutrophils and lymphocytes to each other and PLR was calculated by the ratio of platelets and lymphocytes to each other in whole blood count test result. Patients were divided into 3 groups as normal (HbA1c <6%), prediabetes (HbA1c 6 - 6.4%) and diabetic (HbA1c ? 6.5%). Results: There were statistically significant differences in glucose, CRP, sedimentation, and absolute numbers of neutrophil values (p<0.001, p<0.05, p<0.05 ve p<0.05 respectively) whereas there were no statistically significant differences in absolute lymphocyte count, platelet count, NLR and PLR values between prediabetic, diabetic and control groups. For the tests with differences between the groups when the healthy-prediabetic group is considered there were significant differences for glucose, CRP, sedimentation, and neutrophil count (p<0.05), when the healthy-diabetic group is considered there were significant differences for glucose and CRP (p<0.01 ve p<0.05) and when the prediabetic-diabetic group is considered there was a significant difference only for glucose level (p<0.01). Conclusion: We investigated the relationship between HbA1c values and inflammation markers which are NLR, PLR, CRP and sedimentation in our study. There was no relation between HbA1c and NLR, PLR, sedimentation while there was a relationship between HbA1c and CRP which is a strong inflammatory marker. This suggests that more time and more data are needed for the NLR and PLR values to be routinely used in clinical practice.
For this current study, our aims were to investigate the relationships between HbA1c with neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) which are accepted as new markers of systemic inflammation and the relationships between HbA1c with CRP and sedimentation, which are accepted as strong inflammation markers in healthy, prediabetic and diabetic groups. Materials and Method: Our study was conducted retrospectively from the results of patients who applied to our hospital. Patients, who had glucose, HbA1c, CRP, sedimentation and whole blood test results, were recruited for the research. NLR was calculated by the ratio of the absolute numbers of neutrophils and lymphocytes to each other and PLR was calculated by the ratio of platelets and lymphocytes to each other in whole blood count test result. Patients were divided into 3 groups as normal (HbA1c <6%), prediabetes (HbA1c 6 - 6.4%) and diabetic (HbA1c ? 6.5%). Results: There were statistically significant differences in glucose, CRP, sedimentation, and absolute numbers of neutrophil values (p<0.001, p<0.05, p<0.05 ve p<0.05 respectively) whereas there were no statistically significant differences in absolute lymphocyte count, platelet count, NLR and PLR values between prediabetic, diabetic and control groups. For the tests with differences between the groups when the healthy-prediabetic group is considered there were significant differences for glucose, CRP, sedimentation, and neutrophil count (p<0.05), when the healthy-diabetic group is considered there were significant differences for glucose and CRP (p<0.01 ve p<0.05) and when the prediabetic-diabetic group is considered there was a significant difference only for glucose level (p<0.01). Conclusion: We investigated the relationship between HbA1c values and inflammation markers which are NLR, PLR, CRP and sedimentation in our study. There was no relation between HbA1c and NLR, PLR, sedimentation while there was a relationship between HbA1c and CRP which is a strong inflammatory marker. This suggests that more time and more data are needed for the NLR and PLR values to be routinely used in clinical practice.
Açıklama
Anahtar Kelimeler
Diyabetes Mellitus, HbA1c, Nötrofil lenfosit oranı, Trombosit lenfosit oranı, Diabetes Mellitus, HbA1c, Neutrophil lymphocyte ratio, Platelet lymphocyte ratio
Kaynak
Türk Klinik Biyokimya Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
16
Sayı
2
Künye
Öngen İpek, B. ve Sitar, M.E. (2018). Hba1c değerlerinin inflamatuar belirteçleri ile ilişkisi / Relation of hba1c Levels with inflammatory status markers. Türk Klinik Biyokimya Dergisi, Türk Klinik Biyokimya Derneği. 16(2), s. 83-90.
