Effects of 4% Icodextrin on Experimental Spinal Epidural Fibrosis

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dc.authorid0000-0002-6197-7654en_US
dc.authorid0000-0002-4713-4271en_US
dc.authorid0000-0003-3868-3137en_US
dc.contributor.authorKaranci, Turker
dc.contributor.authorKelten, Bilal
dc.contributor.authorKaraoglan, Alper
dc.contributor.authorCinar, Nilgun
dc.contributor.authorMidi, Ahmet
dc.contributor.authorAntar, Veysel
dc.contributor.authorAkdemir, Hidayet
dc.contributor.authorYalcinkaya Kara, Zeynep Mine
dc.date.accessioned2024-07-12T21:56:40Z
dc.date.available2024-07-12T21:56:40Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAIM: The aim of this experimental study was to investigate whether spinal epidural 4% glucose polymer solution is effective in the prevention of postoperative' ibrosis. MATERIAL and METHODS: Twenty eight adult Wistar albino rats were randomly divided into two equal groups, including treatment and control. Both groups underwent L1 vertebral total laminectomy to expose the dura. Topical treatment group received 4% icodextrin. Four weeks later, epidural fibrosis was examined in both groups histologically, biochemically and macroscopically. RESULTS: Topical use of 4% icodextrin prevented significantly epidural fibrosis following the laminectomy operation. CONCLUSION: Topical 4% icodextrin application inhibits postoperative epidural fibrosis with various mechanisms and prevents adhesions by playing barrier role between tissue surfaces through flotation. Our study is first to present evidence of experimental epidural fibrosis prevention with 4% icodextrin.en_US
dc.identifier.doi10.5137/1019-5149.JTN.15079-15.1
dc.identifier.endpage271en_US
dc.identifier.issn1019-5149
dc.identifier.issue2en_US
dc.identifier.pmid27593771en_US
dc.identifier.scopus2-s2.0-85014839979en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage265en_US
dc.identifier.trdizinid220949en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.15079-15.1
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8586
dc.identifier.volume27en_US
dc.identifier.wosWOS:000395614900015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTURKISH NEUROSURGICAL SOCen_US
dc.relation.ispartofTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03713
dc.subjectEpidural fibrosisen_US
dc.subjectIcodextrinen_US
dc.subjectSpineen_US
dc.titleEffects of 4% Icodextrin on Experimental Spinal Epidural Fibrosisen_US
dc.typeArticle
dspace.entity.typePublication

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