Human serum albumin and its relation with oxidative stress

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dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorSitar, Mustafa Erinç
dc.contributor.authorAydın, Şeval
dc.contributor.authorÇakatay, Ufuk
dc.date.accessioned2024-07-12T21:03:01Z
dc.date.available2024-07-12T21:03:01Z
dc.date.issued2013en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractHuman serum albumin, a negative acute phase reactant and marker of nutritive status, presents at high concentrations in plasma. Albumin has always been used in many clinical states especially to improve circulatory failure. It has been showed that albumin is involved in many bioactive functions such as regulation of plasma osmotic pressure, binding and transport of various endogenous or exogenous compounds, and finally extracellular antioxidant defenses. Molecules like transferrin, caeruloplasmin, haptoglobin, uric acid, bilirubin, alpha-tocopherol, glucose, and albumin constitute extracellular antioxidant defenses in blood plasma but albumin is the most potent one. Most of the antioxidant properties of albumin can be attributed to its unique biochemical structure. The protein possesses antioxidant properties such as binding copper tightly and iron weakly, scavenging free radicals, e.g., hypochlorous acid (HOCl) and Peroxynitrite (ONOOH) and providing thiol group (-SH). Whether it is chronic or acute, during many pathological conditions, biomarkers of oxidative protein damage increase and this observation continues with considerable oxidation of human serum albumin. There is an important necessity to specify its interactions with Reactive Oxygen Species. Generally, it may lower the availability of pro-oxidants and be preferentially oxidized to protect other macromolecules but all these findings make it necessary that researchers give a more detailed explanation of albumin and its relations with oxidative stress.en_US
dc.identifier.citationSitar, M.S., Aydın, S. ve Çakatay, U. (2013). Human serum albumin and its relation with oxidative stress. Clinical Laboratory, Clinical Laboratory Publications GmbH. 59(9-10), s. 945-952.en_US
dc.identifier.endpage952en_US
dc.identifier.issn1433-6510
dc.identifier.issue9.Ekien_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage945en_US
dc.identifier.urihttps://www.clin-lab-publications.com/article/1213
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3617
dc.identifier.volume59en_US
dc.institutionauthorSitar, Mustafa Erinç
dc.language.isoenen_US
dc.publisherClinical Laboratory Publications GmbHen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.isversionof10.7754/Clin.Lab.2012.121115en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00532
dc.titleHuman serum albumin and its relation with oxidative stressen_US
dc.typeArticle
dspace.entity.typePublication

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