Oxidative damage parameters in renal tissues of aged and young rats based on gender

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dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorUzun, Duygu
dc.contributor.authorGüntaş Korkmaz, Gülcan
dc.contributor.authorSitar, Mustafa Erinç
dc.contributor.authorCebe, Tamer
dc.contributor.authorYanar, Karolin
dc.contributor.authorÇakatay, Ufuk
dc.contributor.authorAydın, Şeval
dc.date.accessioned2024-07-12T21:03:01Z
dc.date.available2024-07-12T21:03:01Z
dc.date.issued2013en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractPurpose Aging is characterized by a gradual functional decrease of all systems including the kidneys. Growing evidence links altered lipid protein redox-homeostasis with renal dysfunction. The effect of sexual dimorphism on the lipid protein redox-homeostasis mechanisms in the aging kidney is obscure. In the current study, we aimed to investigate redox homeostasis as it related to sexual dimorphism on protein oxidation and lipid peroxidation parameters, as protein carbonyl (PCO), total thiol (T-SH), advanced oxidation protein products (AOPP), malondialdehyde, glutathione (GSH), and superoxide dismutase (SOD) activity, as potential aging biomarkers, which may contribute to an analysis of the free radical theory of aging. Materials and methods The study was carried out with 16 naturally aged rats (24 months old; eight males and eight females) and their corresponding young rat groups as controls (6 months old; eight males and eight females). All of the aforementioned parameters (PCO, T-SH, AOPP, MDA, GSH, SOD) were measured manually instead of automated devices or ELISA kits. Results PCO, AOPP, and malondialdehyde levels in aged rats were significantly higher in the older rat group than in the younger rat group, whereas SOD activities were significantly lower in old rats. T-SH levels were not significantly different in male groups; however, T-SH levels were lower in the aged female group than in the young female control group. In addition, GSH levels were significantly different between the aged rat group and the corresponding young control group for both genders. Conclusion With respect to PCO and AOPP, impaired redox homeostasis is substantially more prominent in males than females. The decrease of G-SH levels in male groups could be attributed to stabilizing the redox status of protein thiol groups by the depletion of the GSH groups. Considering the results, the renal tissue proteins and lipids in different genders may have different susceptibilities to oxidative damage.en_US
dc.identifier.citationUzun, D., Güntaş Korkmaz, G., Sitar, M.E. vd. (2013). Oxidative damage parameters in renal tissues of aged and young rats based on gender. Clinical Interventions in Aging, National Library of Medicine. 8, s. 809-815.en_US
dc.identifier.endpage815en_US
dc.identifier.issn1178-1998
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage809en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700783/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3616
dc.identifier.volume8en_US
dc.institutionauthorSitar, Mustafa Erinç
dc.language.isoenen_US
dc.publisherNational Library of Medicineen_US
dc.relation.ispartofClinical Interventions in Agingen_US
dc.relation.isversionof10.2147/CIA.S46188en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00530
dc.subjectlipid peroxidationen_US
dc.subjectprotein oxidationen_US
dc.subjectradicalsen_US
dc.subjectrenal agingen_US
dc.titleOxidative damage parameters in renal tissues of aged and young rats based on genderen_US
dc.typeArticle
dspace.entity.typePublication

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