Chondroprotective effect of salicylate and chloroquine in pyogenic septic arthritis

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dc.authorid0000-0003-1829-5700en_US
dc.contributor.authorEren, Abdullah
dc.contributor.authorÜğütmen, Ender
dc.contributor.authorÖzkan, Korhan
dc.contributor.authorTurhan, Yalçın
dc.contributor.authorEceviz, Engin
dc.contributor.authorÇilli, Feridun
dc.date.accessioned2024-07-12T21:01:19Z
dc.date.available2024-07-12T21:01:19Z
dc.date.issued2008en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIntroduction This study aims to investigate the effectiveness of salicylate (Aspisol®; Bayer AG, Leverkusen, Germany) and chloroquine on preventing cartilage damage in septic arthritis. Methods A septic arthritis model was created by inoculating the knee joint of young rabbits (n=21) with Staphylococcus aureus. Some rabbits with inflicted septic arthritis did not undergo any treatment and served as the control group (n=7). The second group (n=7) was started on salicylate on day 2 to investigate the effects of salicylate on joint cartilage. The third group (n=7) was started on chloroquine on day 2 to investigate the effects of chloroquine on joint cartilage. All three groups underwent arthrotomy, drainage and synoviectomy on day 7 of the experiment. Animals were sacrificed on day 14 and the joint cartilages were extracted. Histopathology, determination of local prostaglandin (PGE)-like activity, and evaluation of hyaluronic acid loss were performed on all samples. Results The control group and the salicylate group were similar in the extent of joint damage. Salicylate did not prevent joint cartilage damage despite inhibiting PGE synthesis. Chloroquine, despite not inhibiting PGE synthesis, did prevent cartilage destruction. Conclusion If supported by larger-scale studies, chloroquine could be added to the antibiotic regimen in the treatment of septic arthritis to prevent cartilage damage.en_US
dc.identifier.citationEren, A., Üğütmen, E., Özkan, K. vd. (2008). Chondroprotective effect of salicylate and chloroquine in pyogenic septic arthritis. Advances in Therapy, SpringerLink. 25, s. 133-142.en_US
dc.identifier.endpage142en_US
dc.identifier.issn0741-238X
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s12325-008-0020-3
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3488
dc.identifier.volume25en_US
dc.institutionauthorÜğütmen, Ender
dc.language.isoenen_US
dc.publisherSpringerLinken_US
dc.relation.ispartofAdvances in Therapyen_US
dc.relation.isversionof10.1007/s12325-008-0020-3en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00107
dc.subjectchloroquineen_US
dc.subjectpyogenic septic arthritisen_US
dc.subjectsalicylateen_US
dc.titleChondroprotective effect of salicylate and chloroquine in pyogenic septic arthritisen_US
dc.typeArticle
dspace.entity.typePublication

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