Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder

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dc.contributor.authorAtmaca, Murad
dc.contributor.authorYildirim, Hanefi
dc.contributor.authorOzdemir, Huseyin
dc.contributor.authorKoc, Mustafa
dc.contributor.authorOzler, Sinan
dc.contributor.authorTezcan, Ertan
dc.date.accessioned2024-07-12T21:52:53Z
dc.date.available2024-07-12T21:52:53Z
dc.date.issued2009en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAim: To date, despite possible neuroanatomical importance, no magnetic resonance spectroscopy (MRS) study on hippocampus has been performed in obsessive-compulsive disorder (OCD). The purpose of the present study was therefore to compare hippocampal chemicals in patients with OCD with those in healthy subjects with no psychopathology. Methods: Eighteen patients meeting DSM-IV criteria for OCD and 18 healthy controls were studied. The patients and controls underwent proton magnetic resonance spectroscopy ((1)H-MRS), and measures of N-acetyl-l-aspartate (NAA), choline (CHO), and creatine (CRE) in hippocampal regions were obtained. Results: Both NAA/CRE and NAA/CHO ratios in the hippocampus in patients with OCD were reduced relative to healthy controls. The ANOVA showed a near-significant effect of diagnosis for NAA/CRE and a significant effect for NAA/CHO, but the ANOVA did not show any significant effect even at a trend level for CHO/CRE. No main effect of hemisphere was found for any metabolite ratio. Conclusions: The presence of neuronal degeneration is suggested in OCD. Future longitudinal neuroimaging and neuropsychological studies with larger patient samples are warranted in order to confirm these preliminary findings to better characterize the relevance of neurochemical abnormalities in hippocampus in the pathophysiology of OCD.en_US
dc.identifier.doi10.1111/j.1440-1819.2009.01993.x
dc.identifier.endpage490en_US
dc.identifier.issn1323-1316
dc.identifier.issue4en_US
dc.identifier.pmid19531109en_US
dc.identifier.scopus2-s2.0-68149176461en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage486en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1440-1819.2009.01993.x
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8439
dc.identifier.volume63en_US
dc.identifier.wosWOS:000268101000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELL PUBLISHING, INCen_US
dc.relation.ispartofPSYCHIATRY AND CLINICAL NEUROSCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03315
dc.subjectcholineen_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.subjectN-acetylaspartateen_US
dc.subjectobsessive-compulsive disorderen_US
dc.subjectspectroscopyen_US
dc.titleNeurochemistry of the hippocampus in patients with obsessive-compulsive disorderen_US
dc.typeArticle
dspace.entity.typePublication

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