An analysis of neuropeptides at nasal contact points of patients with secondary headache

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dc.authorid0000-0001-7914-2201en_US
dc.contributor.authorDemir, Deniz
dc.contributor.authorCengiz, Nureddin
dc.contributor.authorGüven, Mehmet
dc.contributor.authorBulduk, Oğuzhan
dc.contributor.authorDemir, Deniz
dc.date.accessioned2024-07-12T21:00:37Z
dc.date.available2024-07-12T21:00:37Z
dc.date.issued2016en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjectives: This prospective research study was designed to analyze the surgical outcomes and the intensity of substance P (SP), neurokinin A (NA), and calcitonin gene-related peptide (CGRP) in contact and noncontact nasal mucosa of patients with headache. Methods: Twenty adults with secondary headache and correctible nasal obstruction were included in this study. The patients had nasal contact points between the nasal septum and the middle or inferior turbinates on nasal endoscopy and computed tomography scan. During surgical procedures, sample tissues were obtained from the nasal contact point and the noncontact area of the lateral nasal wall of these patients. Fluorescein staining intensity for antibodies against SP, NA, and CGRP was analyzed using image J software. Headaches were evaluated using a visual analog scale preoperatively and postoperatively. Results: The differences between the preoperative and the postoperative 3rd month (P < 0.001) and 12th month (P < 0.001) visual analog scale scores were statistically significant. However, fluorescein staining intensity for SP (P = 0.631), NA (P = 0.546), and CGRP (P = 0.683) did not show statistically significant differences between the contact mucosa and the noncontact mucosa groups. Conclusions: Although in selected patients significant relief of headache can be obtained by surgery, there is no evidence from this study that SP, NA, and CGRP are responsible for the initiation of headache.en_US
dc.identifier.citationDemir, D., Cengiz, N., Güven, M. ve Bulduk, O. (2016). An analysis of neuropeptides at nasal contact points of patients with secondary headache. Journal of Craniofacial Surgery, Wolters Kluwer. 27(3), s. 305-309.en_US
dc.identifier.endpage309en_US
dc.identifier.issn1536-3732
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage305en_US
dc.identifier.urihttps://journals.lww.com/jcraniofacialsurgery/Fulltext/2016/05000/An_Analysis_of_Neuropeptides_at_Nasal_Contact.110.aspx
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3404
dc.identifier.volume27en_US
dc.institutionauthorDemir, Deniz
dc.language.isoenen_US
dc.publisherWolters Kluweren_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.isversionof10.1097/SCS.0000000000002553en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01877
dc.subjectCalcitonin gene-related peptideen_US
dc.subjectendoscopic nasal surgeryen_US
dc.subjectnasal septal deviationen_US
dc.subjectneurokinin Aen_US
dc.subjectneuropeptidesen_US
dc.titleAn analysis of neuropeptides at nasal contact points of patients with secondary headacheen_US
dc.typeArticle
dspace.entity.typePublication

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