Effects of Different Calorie Restriction Protocols on Oxidative Stress Parameters in a Transgenic Mouse Model of Breast Cancer

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dc.authoridYılmaz, Bayram/0000-0002-2674-6535en_US
dc.authoridThomas, Pınar Buket/0000-0001-7627-0291en_US
dc.contributor.authorÇiçekdal, Münevver B.
dc.contributor.authorThomas, Pınar B.
dc.contributor.authorTuna, Bilge Güvenc
dc.contributor.authorCharehsaz, Mohammad
dc.contributor.authorAydın, Ahmet
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorCleary, Margot P.
dc.date.accessioned2024-07-12T21:37:59Z
dc.date.available2024-07-12T21:37:59Z
dc.date.issued2022en_US
dc.department[Belirlenecek]en_US
dc.description.abstractAging and diseases related to aging, such as cancer, have been linked to oxidative stress. On the other hand, calorie restriction (CR) is one of the most effective interventions to slow down aging and prevent a variety of diseases such as cancer in preclinical models. CR has also been reported to modify oxidative stress. The aim of this study was to investigate the effects of different CR protocols and aging on oxidative stress parameters in the MMTV-TGF-alpha breast cancer mouse model in a cross-sectional study. Female mice were randomly enrolled in three groups: ad libitum (AL), chronic calorie restriction (CCR, 15% CR) or intermittent calorie restriction (ICR, three weeks AL followed by one week 60% CR in cyclic periods) starting at the age of 10 weeks until 81/82 weeks of age. Liver samples were analyzed for malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px) levels. At week 49/50, the GSH level increased significantly in the CCR group compared to the AL and ICR-R groups which had higher mammary tumor (MT) incidence rates. Additionally, liver MDA levels in ICR groups were significantly increased, while aging led to decreased CAT and SOD activities in all CR groups. The application of different CR protocols did not have any significant effect on MDA, CAT, and SOD parameters in the liver at week 81/82. These results suggest that although GSH may interfere with MT development at the systemic level, many of the oxidative stress parameters may have more local effects on tumor development than the systemic effects.en_US
dc.identifier.doi10.7759/cureus.27895
dc.identifier.issn2168-8184
dc.identifier.issue8en_US
dc.identifier.pmid36120244en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.27895
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7011
dc.identifier.volume14en_US
dc.identifier.wosWOS:000933408300025en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCureus Incen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04353
dc.subjectAgeingen_US
dc.subjectMouse Modelen_US
dc.subjectBreast Canceren_US
dc.subjectOxidative Stressen_US
dc.subjectIntermittent Calorie Restrictionen_US
dc.titleEffects of Different Calorie Restriction Protocols on Oxidative Stress Parameters in a Transgenic Mouse Model of Breast Canceren_US
dc.typeArticle
dspace.entity.typePublication

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