Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women

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dc.authorid0000-0002-3166-9052en_US
dc.authorid0000-0002-4627-8628en_US
dc.authorid0000-0003-2802-7793en_US
dc.contributor.authorHaliloglu, Berna
dc.contributor.authorAksungar, Fehime Benli
dc.contributor.authorIlter, Erdin
dc.contributor.authorPeker, Hakan
dc.contributor.authorAkin, Figen Temelli
dc.contributor.authorOzekici, Umit
dc.date.accessioned2024-07-12T21:45:05Z
dc.date.available2024-07-12T21:45:05Z
dc.date.issued2010en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractWe aimed to investigate whether levels of homocysteine (Hcy), folate, and vitamin B12 are related to bone turnover markers and bone mineral density (BMD) in postmenopausal women. One hundred and twenty postmenopausal women were divided into three groups: osteoporotic, osteopenic and normal, according to the BMD measurements. The age, weight, body mass index (BMI), years since menopause (YSM), gravidity, parity, bone turnover markers [type I collagen C-telopeptides (CTx) and bone-specific alkaline phosphatase (BAP)], serum Hcy, parathyroid hormone (PTH), vitamin B12, folate, calcium and magnesium levels were compared with each other. Twenty-five women had osteoporotic, 42 women had osteopenic, and 53 had normal BMD values. After adjusting for confounding factors, serum Hcy levels were significantly higher in osteoporotic women [adj OR = 38.95 (1.474-1029.88) p = 0.02]. The age, YSM, PTH, CTx and BAP levels were related to serum Hcy in all women (beta = 0.523, p = 0.0001; beta = 0.446, p = 0.001; beta = 0.295, p = 0.005; beta = 0.239, p = 0.026; beta = 0.451, p = 0.001, respectively). Our data showed that vitamin B12, folate and Hcy levels were not related with BMD in postmenopausal women. We think that one of the underlying mechanisms of increased Hcy levels and osteoporosis may be a mechanistic link which cannot detected by BMD or biochemical markers.en_US
dc.identifier.doi10.1007/s00404-009-1297-4
dc.identifier.endpage668en_US
dc.identifier.issn0932-0067
dc.identifier.issue4en_US
dc.identifier.pmid19946695en_US
dc.identifier.scopus2-s2.0-77950627195en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage663en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-009-1297-4
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7792
dc.identifier.volume281en_US
dc.identifier.wosWOS:000275398300014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00318
dc.subjectMenopauseen_US
dc.subjectVitamin B12en_US
dc.subjectFolateen_US
dc.subjectHomocysteineen_US
dc.subjectBoneen_US
dc.titleRelationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal womenen_US
dc.typeArticle
dspace.entity.typePublication

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