The Relationship Between Gamma-Glutamyl Transferase Levels and Coronary Plaque Burdens and Plaque Structures in Young Adults With Coronary Atherosclerosis

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dc.authorid0000-0002-6253-3318en_US
dc.contributor.authorCelik, Omer
dc.contributor.authorCakmak, Huseyin Altug
dc.contributor.authorSatilmis, Seckin
dc.contributor.authorGungor, Baris
dc.contributor.authorAkin, Fatih
dc.contributor.authorOzturk, Derya
dc.contributor.authorYalcin, Ahmet Arif
dc.contributor.authorAyca, Burak
dc.contributor.authorErturk, Mehmet
dc.contributor.authorAtasoy, Mehmet Mahir
dc.contributor.authorUslu, Nevzat
dc.date.accessioned2024-07-12T21:45:44Z
dc.date.available2024-07-12T21:45:44Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Elevated gamma-glutamyl transferase (GGT) levels have been demonstrated to be associated with poor prognoses in patients with coronary artery disease. Coronary computed tomography angiography (CCTA) is a noninvasive imaging modality that may differentiate the structure of coronary plaques. Elevated plaque burdens and noncalcified plaques, detected by CCTA, are important predictors of atherosclerosis in young adults. Hypothesis: The present study investigated the possible relationship between GGT levels and coronary plaque burdens/structures in young adults with coronary atherosclerosis. Methods: CCTA images of 259 subjects were retrospectively examined, and GGT levels were compared between patients with coronary plaques and individuals with normal coronary arteries. Coronary plaques, detected by CCTA, were categorized as noncalcified, calcified, and mixed, according to their structures. The significant independent predictors of coronary atherosclerosis were also analyzed using multivariate logistic regression analysis. Results: GGT levels were significantly higher in patients with coronary plaque formation than in controls (35.7 +/- 14.7 vs 19.6 +/- 10.0 U/L; P < 0.001). GGT levels were also positively correlated with the number of plaques; presence of noncalcified plaques; and levels of high-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c, uric acid, and triglycerides. Moreover, smoking and levels of GGT, hs-CRP, uric acid, and low high-density lipoprotein cholesterol were independent predictors of coronary atherosclerosis. Conclusions: GGT is an inexpensive and readily available marker that provides additional risk stratification beyond that provided by conventional risk factors for predicting coronary plaque burdens and plaque structures in young adults.en_US
dc.identifier.doi10.1002/clc.22307
dc.identifier.endpage557en_US
dc.identifier.issn0160-9289
dc.identifier.issn1932-8737
dc.identifier.issue9en_US
dc.identifier.pmid25197023en_US
dc.identifier.scopus2-s2.0-84908267332en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage552en_US
dc.identifier.urihttps://dx.doi.org/10.1002/clc.22307
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7853
dc.identifier.volume37en_US
dc.identifier.wosWOS:000342236900007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofCLINICAL CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00512
dc.titleThe Relationship Between Gamma-Glutamyl Transferase Levels and Coronary Plaque Burdens and Plaque Structures in Young Adults With Coronary Atherosclerosisen_US
dc.typeArticle
dspace.entity.typePublication

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