Serotonin dilemma in postmenopausal women: Is it low or high?

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dc.authorid0000-0002-3166-9052en_US
dc.authorid0000-0002-4627-8628en_US
dc.contributor.authorHaliloglu, Berna
dc.contributor.authorAksungar, Fehime Berth
dc.contributor.authorIlter, Erdin
dc.contributor.authorAkin, Figen Temelli
dc.contributor.authorMutlu, Nilgun
dc.contributor.authorPeker, Hakan
dc.contributor.authorOzden, Selcuk
dc.date.accessioned2024-07-12T21:51:52Z
dc.date.available2024-07-12T21:51:52Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: In this study, we have studied with premenopausal (PM), naturally menopausal (NM) and surgically induced menopausal (SM) women in order to investigate the differences in serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), follicle stimulating hormone (FSH) and estradiol (E2) levels on serum serotonin levels. Methods: Forty premenopausal (36.7 +/- 3.5 years), 40 naturally menopausal (54.2 +/- 8.4 years) and 38 surgically induced menopausal (55.4 +/- 11.2 years) women were included in the study. None of the subjects were using antidepressants or hormone replacement therapy. In NM and SM, years since menopause (YSM) were 3.16 +/- 1.58 and 3.36 +/- 1.89, respectively. Cortisol, DHEA-S, FSH and E2 levels were determined by immunochemiluminisence while serotonin levels were determined by HPLC. Results: Serum serotonin levels in NM women were higher than the other two groups [144.23 +/- 45.29 mu g/L vs 61.35 +/- 37.72 mu g/L in SM women and 98.74 +/- 50.29 mu g/L in PM women]. E2 and DHEA-S were positively correlated, while FSH and cortisol were negatively correlated with serotonin in NM and SM. There was no significant correlation between serotonin and age or YSM. In the PM group, there was no significant correlation between serotonin and the hormones. Conclusion: In conclusion, increased serotonin levels in naturally menopausal women may be a compensatory mechanism to decreased E2 levels as it is postulated that there is strong interaction between E2 and the serotoninergic system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.maturitas.2008.04.013
dc.identifier.endpage152en_US
dc.identifier.issn0378-5122
dc.identifier.issn1873-4111
dc.identifier.issue2en_US
dc.identifier.pmid18554829en_US
dc.identifier.scopus2-s2.0-45849100494en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.maturitas.2008.04.013
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8327
dc.identifier.volume60en_US
dc.identifier.wosWOS:000258048700008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.relation.ispartofMATURITASen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02872
dc.subjectserotoninen_US
dc.subjectmenopauseen_US
dc.subjectestradiolen_US
dc.subjectcortisolen_US
dc.subjectDHEA-Sen_US
dc.subjectFSHen_US
dc.titleSerotonin dilemma in postmenopausal women: Is it low or high?en_US
dc.typeArticle
dspace.entity.typePublication

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