Does partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction?

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dc.contributor.authorOzden, Burcu Celet
dc.contributor.authorGuven, Erdem
dc.contributor.authorAslay, Isik
dc.contributor.authorKemikler, Gonul
dc.contributor.authorOlgac, Vakur
dc.contributor.authorTekkesin, Merva Soluk
dc.contributor.authorSerarslan, Bengul
dc.contributor.authorUlug, Burcak Tumerdem
dc.contributor.authorKarabulut, Aylin Bilgin
dc.contributor.authorArinci, Atilla
dc.contributor.authorEmekli, Ufuk
dc.date.accessioned2024-07-12T21:57:12Z
dc.date.available2024-07-12T21:57:12Z
dc.date.issued2012en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: The optimum protocol for expander volume adjustment with respect to the timing and application of radiotherapy remains controversial. Methods: Eighteen New Zealand rabbits were divided into three groups. Metallic port integrated anatomic breast expanders of 250 cc were implanted on the back of each animal and controlled expansion was performed. Group I underwent radiotherapy with full expanders while in Group II, expanders were partially deflated immediately prior to radiotherapy. Control group did not receive radiotherapy. The changes in blood flow at different volume adjustments were investigated in Group II by laser Doppler flowmetry. Variations in the histopathologic properties of the irradiated tissues including the skin, capsule and the pocket floor, were compared in the biopsy specimens taken from different locations in each group. Results: A significant increase in skin blood flow was detected in Group II with partial expander deflation. Overall, histopathologic exam revealed aggravated findings of chronic radiodermatitis (epidermal atrophy, dermal inflammation and fibrosis, neovascularisation and vascular changes as well as increased capsule thickness) especially around the lower expander pole, in Group II. Conclusions: Expander deflation immediately prior to radiotherapy, may augment the adverse effects, especially in the lower expander pole, possibly via enhanced radiosensitization due to a relative increase in the blood flow and tissue oxygenation.en_US
dc.identifier.doi10.1186/1477-7819-10-44
dc.identifier.issn1477-7819
dc.identifier.pmid22348433en_US
dc.identifier.scopus2-s2.0-84857136101en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1186/1477-7819-10-44
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8651
dc.identifier.volume10en_US
dc.identifier.wosWOS:000302415500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBIOMED CENTRAL LTDen_US
dc.relation.ispartofWORLD JOURNAL OF SURGICAL ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04028
dc.subjectTwo-stage breast reconstructionen_US
dc.subjectRadiotherapyen_US
dc.subjectTissue expansionen_US
dc.titleDoes partial expander deflation exacerbate the adverse effects of radiotherapy in two-stage breast reconstruction?en_US
dc.typeArticle
dspace.entity.typePublication

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