Slx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Oxford University Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Chronological lifespan (CLS) in budding yeast Saccharomyces cerevisiae, which is defined as the time nondividing cells in saturation remain viable, has been utilized as a model to study post-mitotic aging in mammalian cells. CLS is closely related to entry into and maintenance of a quiescent state. Many rearrangements that direct the quiescent state enhance the ability of cells to endure several types of stress. SUMO-targeted ubiquitin ligases (STUbLs) play a critical role in mediating an adaptive response to various stresses. In this study, we investigated the effect of a STUbL, Slx5/Slx8, on CLS in budding yeast. We showed that both SLX5 and SLX8 deletions accelerate chronological aging, resulting in a decreased maximum and mean lifespan. slx5Δ cells were capable of entering or maintaining a quiescent state during aging. On the other hand, aging slx5Δ and slx8Δ cells had both increased spontaneous mutation accumulation. Our data together indicate that Slx5/Slx8 STUBL is required for normal rate of aging by preventing increased spontaneous mutation accumulation during aging.
Açıklama
Anahtar Kelimeler
Slx5/Slx8 STUbL (Sumo-Targeted Ubiquitin Ligase), Chronological Aging, Quiescence, Mutation Accumulation, Saccharomyces Cerevisiae
Kaynak
FEMS Microbiology Letters
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Thomas, P. B., Kaluç, N., Çavli, I. N. ve Tuna, B. G. (2024). Slx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast, FEMS Microbiology Letters, Oxford University Press,--.
