Effects of hormone replacement therapy on glucose and lipid profiles and on cardiovascular risk parameters in postmenopausal women

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dc.contributor.authorBingol, Banu
dc.contributor.authorGunenc, Ziya
dc.contributor.authorYilmaz, Murat
dc.contributor.authorBiri, Aydan
dc.contributor.authorTiras, Buelent
dc.contributor.authorGuner, Haldun
dc.date.accessioned2024-07-12T21:45:05Z
dc.date.available2024-07-12T21:45:05Z
dc.date.issued2010en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effects of hormone replacement therapy (HRT) on carbohydrate and lipid metabolisms and cardiovascular risk parameters in healthy postmenopausal women. Forty women receiving and 38 women not receiving HRT were included and baseline and sixth month blood pressure, weight, body mass index, waist/hip ratio, blood lipid profile, inflammatory markers (homocysteine, C-reactive protein (CRP) and fibrinogen), hemoglobin A1c (HbA1c) and insulin, and oral glucose tolerance test (OGTT) results were evaluated. The mean age was 52.6 +/- A 4.9 and 52.2 +/- A 5.0 years in the HRT and Control Groups, respectively. Whereas there was no change in the Controls, the weight, waist/hip ratio, and BMI increased and diastolic blood pressure decreased in the HRT patients. LDL-c, VLDL-c and lipoprotein (a) levels were significantly higher in the HRT Group in the sixth month; however, total cholesterol and LDL-c increased in the Controls but VLDL-c and lipoprotein (a) did not. CRP and homocysteine significantly increased and fibrinogen decreased, whereas in the Control Group no significant change was detected. A significant improvement in HbA1c and OGTT was found in both the groups, whereas a significant reduction was measured only in the HRT Group. In response to 6 months of HRT, there was an increase in weight, BMI, and waist/hip ratio as known cardiovascular risk factors, but no significant impact on lipid profile and glucose metabolism could have been clearly demonstrated. A mixed effect profile of HRT on the state of inflammation (increase in CRP and homocysteine, decrease in fibrinogen) was observed.en_US
dc.identifier.doi10.1007/s00404-009-1169-y
dc.identifier.endpage864en_US
dc.identifier.issn0932-0067
dc.identifier.issue5en_US
dc.identifier.pmid19593578en_US
dc.identifier.scopus2-s2.0-77950630113en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage857en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-009-1169-y
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7793
dc.identifier.volume281en_US
dc.identifier.wosWOS:000276265100012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00319
dc.subjectHormone replacement therapyen_US
dc.subjectC-reactive proteinen_US
dc.subjectCarbohydrate and lipid metabolismen_US
dc.subjectCardiovascular risken_US
dc.subjectHomocysteineen_US
dc.subjectFibrinogenen_US
dc.titleEffects of hormone replacement therapy on glucose and lipid profiles and on cardiovascular risk parameters in postmenopausal womenen_US
dc.typeArticle
dspace.entity.typePublication

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