Comparison of oxidative stress biomarkers in renal tissues of D-galactose induced, naturally aged and young rats

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dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorAydın, Şeval
dc.contributor.authorYanar, Karolin
dc.contributor.authorAtukeren, Pınar
dc.contributor.authorDalo, Enis
dc.contributor.authorSitar, Mustafa Erinç
dc.contributor.authorUslu, Ezel
dc.contributor.authorCaf, Nazlı
dc.contributor.authorÇakatay, Ufuk
dc.date.accessioned2024-07-12T21:02:07Z
dc.date.available2024-07-12T21:02:07Z
dc.date.issued2012en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractAgeing of kidneys is a clinical health issue of the society. Age-related renal insufficiency has important implications due to impaired redox homeostasis. We examined protein, DNA and lipid oxidation biomarkers as well as protein-bound sialic acid (SA) in the kidney tissues of D-galactose induced ageing rats, naturally aged rats and their corresponding young control group. Intraperitoneal injection of D-galactose (60 mg/kg/day) for 6 weeks to young male Sprague–Dawley rats (20-week-old) was used to establish mimetic ageing model. In this study, we investigated the levels of protein carbonyl groups (PCO), various thiol fractions such as total thiol groups (T-SH), protein (P-SH) and non-protein thiol groups (NP-SH), lipid oxidation parameters such as lipid hydroperoxides (LHP) and malondialdehyde (MDA), SA and 8-hydroxy-2?deoxyguanosine (8-OHdG) parameters for comparison of naturally aged, induced aged and young rats. In D-galactose induced aged group, PCO, LHP, MDA, and 8-OHdG concentrations were significantly higher than young control group, whereas T-SH, P-SH levels were significantly lower than the young rats. In addition, NP-SH and SA concentrations were similar between the mimetic ageing and young control groups. In naturally ageing rats, PCO and MDA levels were significantly higher, whereas T-SH, P-SH, NP-SH concentrations were low compared to young controls. On the other hand, SA and 8-OHdG levels were not different between the naturally ageing group and the young control group. Our results demonstrated that the rats in the mimetic ageing group, have significant similarities with the naturally aged rats in terms of impaired redox homeostasis and can be used as a reliable animal model for renal ageing.en_US
dc.identifier.citationAydın, Ş., Yanar, K., Atukeren, P. vd. (2012). Comparison of oxidative stress biomarkers in renal tissues of D-galactose induced, naturally aged and young rats. Biogerontology, Springer. 13, s. 251-260.en_US
dc.identifier.endpage260en_US
dc.identifier.issn1573-6768
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s10522-011-9370-3
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3582
dc.identifier.volume13en_US
dc.institutionauthorSitar, Mustafa Erinç
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBiogerontologyen_US
dc.relation.isversionof10.1007/s10522-011-9370-3en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00423
dc.subjectAgeing modelen_US
dc.subjectD-Galactoseen_US
dc.subjectKidneyen_US
dc.subjectLipid peroxidationen_US
dc.subjectOxidative DNA damageen_US
dc.subjectProtein oxidationen_US
dc.titleComparison of oxidative stress biomarkers in renal tissues of D-galactose induced, naturally aged and young ratsen_US
dc.typeArticle
dspace.entity.typePublication

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