Coagulation status and biochemical and inflammatory markers in multiple sclerosis

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dc.authorid0000-0003-2016-9965en_US
dc.authorid0000-0003-2016-9965en_US
dc.contributor.authorAksungar, Fehime B.
dc.contributor.authorTopkaya, Aynur E.
dc.contributor.authorYildiz, Zeynep
dc.contributor.authorSahin, Sevki
dc.contributor.authorTurk, Ulku
dc.date.accessioned2024-07-12T21:50:34Z
dc.date.available2024-07-12T21:50:34Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractMultiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system and is the most common cause of neurologic disability in young adults. in this study, the coagulation status and biochemical and non-specific inflammatory markers in patients with MS were investigated. Plasma prothrombin time, activated partial thrombin time, fibrinogen, D-dimer, serum high sensitive C-reactive protein, homocysteine, blood urea nitrogen, creatinine, calcium, total protein, albumin, total cholesterol, vitamin B 12, folate levels and erythrocyte sedimentation rate were measured in 42 patients with MS and 31 healthy subjects as a control group. There was a positive correlation between homocysteine and D-dimer levels (r = 0.84, p < 0.01). However, there was no significant correlation between homocysteine, vitamin B12 (r = 0.18) and folate (r = 0.23) levels. Serum total protein, albumin and calcium levels of MS patients were lower than the control group. There are some alterations in the coagulation and biochemical status in MS patients. These findings may contribute to better understanding of the etiopathogenesis and clinical characteristics of this disease. (C) 2007 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2007.02.090
dc.identifier.endpage397en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue4en_US
dc.identifier.pmid18258432en_US
dc.identifier.scopus2-s2.0-39649083337en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jocn.2007.02.090
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8166
dc.identifier.volume15en_US
dc.identifier.wosWOS:000254268100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofJOURNAL OF CLINICAL NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01844
dc.subjectMSen_US
dc.subjectcoagulationen_US
dc.subjectD-dimeren_US
dc.subjecthomocysteineen_US
dc.subjectCRPen_US
dc.subjectfibrinogenen_US
dc.titleCoagulation status and biochemical and inflammatory markers in multiple sclerosisen_US
dc.typeArticle
dspace.entity.typePublication

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