Glutamine enhances the heat shock protein 70 expression as a cardioprotective mechanism in left heart tissues in the presence of diabetes mellitus

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dc.authorid0000-0001-6643-9364en_US
dc.authorid0000-0002-0547-9722en_US
dc.authorid0000-0002-9549-0633en_US
dc.authorid0000-0003-0970-7339en_US
dc.authorid0000-0003-4579-7087en_US
dc.authorid0000-0001-5427-550Xen_US
dc.authorid0000-0002-9394-4048en_US
dc.authorid0000-0001-6052-2773en_US
dc.contributor.authorUğurlucan, Murat
dc.contributor.authorErer, Dilek
dc.contributor.authorKaratepe, Oğuzhan
dc.contributor.authorZiyade, Sedat
dc.contributor.authorHaholu, Aptullah
dc.contributor.authorGüngör Uğurlucan, Funda
dc.contributor.authorTireli, Emin
dc.contributor.authorDayıoğlu, Enver
dc.contributor.authorAlpagut, Ufuk İbrahim
dc.date.accessioned2024-07-12T21:04:37Z
dc.date.available2024-07-12T21:04:37Z
dc.date.issued2010en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective: Effects of diabetes mellitus on myocardium were investigated, by assessing levels of heat shock protein (HSP) 70, and efficacy of glutamine was tested. Materials and Methods: Thirty male rats were divided into three groups: control group (Group 1), diabetic group (Group 2) and glutamine-induced diabetic group (Group 3). Diabetes was created by intravenous streptozocin injection. Rats were examined one month later for cardiac complications of diabetes. Serum and tissue samples were obtained to measure HSP 70 levels. Results: Following streptozocin administration, glucose levels increased markedly. This resulted in a significant increase in HSP 70 in serum and tissues. When Group 3 was compared with other groups, HSP 70 was more increased in serum and tissues. When Groups 2 and 3 were compared, more increased HSP 70 values were observed in Group 3, statistical significance was obtained for left atrial and left ventricular HSP 70 levels. Elevated blood glucose was correlated with elevated HSP 70 levels. Increased serum HSP 70 levels were correlated with tissue HSP 70 values. Conclusions: HSP 70 levels increase in the myocardium of rats in diabetes mellitus as a protective mechanism. Levels of HSP 70 may further be increased with parenteral administration of glutamine. Efficacy of glutamine is more pronounced in left heart structures.en_US
dc.identifier.citationUgurlucan, M., Erer, D., Karatepe, O., Ziyade, S., Haholu, A., Gungor Ugurlucan, F., Filizcan, U., Tireli, E., Dayioglu, E., & Alpagut, U. (2010). Glutamine enhances the heat shock protein 70 expression as a cardioprotective mechanism in left heart tissues in the presence of diabetes mellitus. Expert opinion on therapeutic targets, Taylor and Francis Online. 14(11), s. 1143–1156.en_US
dc.identifier.endpage1156en_US
dc.identifier.issn1472-8222
dc.identifier.issn1744-7631
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1143en_US
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1517/14728222.2010.521500?journalCode=iett20
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3793
dc.identifier.volume14en_US
dc.institutionauthorFilizcan, Uğur
dc.language.isoenen_US
dc.publisherTaylor and Francis Onlineen_US
dc.relation.ispartofJournal Expert Opinion on Therapeutic Targetsen_US
dc.relation.isversionof10.1517/14728222.2010.521500en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY01778
dc.subjectatherosclerosisen_US
dc.subjectdiabetes mellitusen_US
dc.subjectglutamineen_US
dc.subjectheat shock protein 70en_US
dc.subjectmyocardiumen_US
dc.titleGlutamine enhances the heat shock protein 70 expression as a cardioprotective mechanism in left heart tissues in the presence of diabetes mellitusen_US
dc.typeArticle
dspace.entity.typePublication

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